Early activity after strong sutures helps to tendon healing in a rat tendon rupture model.

The purpose of this study was to investigate the effect of different times return to activity on tendon healing after Double Kessler method suture in rats with Achilles tendon rupture. The left Achilles tendon of 80 10-week-old rats was repaired. The rats were randomly divided into 4 groups: non-fixed group, fixed one week group, fixed two weeks group and fixed three weeks group.

Development of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil.

Plant extracts, especially herbal extracts, are in line with the cosmetics development trend of natural and safe in today's world. Dried ginger essential oil (DGEO) is a fragrant oily liquid extracted from the dried roots of Zingiber officinale Rosc. This research investigated DGEO could effectively inhibit Staphylococcus aureus and Propionibacterium acnes.

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.

Glucose metabolism has been studied extensively, but the role of glucose-derived excretory glycerol remains unclear. Here we show that hypoxia induces NADH accumulation to promote glycerol excretion and this pathway consumes NADH continuously, thus attenuating its accumulation and reductive stress. Aldolase B accounts for glycerol biosynthesis by forming a complex with glycerol 3-phosphate dehydrogenases GPD1 and GPD1L.

CoGraphNet for enhanced text classification using word-sentence heterogeneous graph representations and improved interpretability.

Text Graph Representation Learning through Graph Neural Networks (TG-GNN) is a powerful approach in natural language processing and information retrieval. However, it faces challenges in computational complexity and interpretability. In this work, we propose CoGraphNet, a novel graph-based model for text classification, addressing key issues.

Experiment and numerical analysis of prestressed unequal-walled rectangular concrete-filled steel box beams.

When long-span beams undergo large, the strength of the beam material cannot be fully utilized. To solve this problem, a prestressed unequal-walled rectangular concrete-filled steel box (PURCFSB) beam is proposed in this paper. The prestressing is added to the concrete-filled steel tubular (CFST) beam and the section is designed.

Non-uniform failure mechanism and stability control of mining roadway under deviatoric stress field.

Based on the elastic-plastic theory, the analytical formula of the second invariant J of deviatoric stress at any point around the circular roadway under the non-uniform stress field is derived. The distribution law of J of surrounding rock under the three-dimensional non-isobaric stress field is studied by theoretical analysis and numerical simulation. Combined with the butterfly failure theory of surrounding rock of roadway, the close relationship between the distribution pattern of J and the distribution pattern of plastic zone is found, and the failure mechanism of surrounding rock is revealed.

Investigating the relationship between built environment and urban vitality using big data.

Urban vitality reflects the dynamic interaction between residents' activities and the urban environment, playing a pivotal role in fostering social and economic development. It enhances urban quality, competitiveness, and residents' well-being. Despite extensive scholarly attention, previous research has often overlooked the integration of big data and the spatial heterogeneity inherent in urban environments.

5,7-Dihydroxyflavone acts on eNOS to achieve hypotensive effects in spontaneously hypertensive rats.

Hypertension is one of the most serious chronic diseases. This study will focus on the systemic antihypertensive mechanisms of 5,7-dihydroxyflavone from in silico simulations to in vivo validations. In-silico studies were applied by network pharmacology, molecular docking, and molecular dynamic simulation.

Incidental iron oxide nanoclusters drive confined Fenton-like detoxification of solid wastes towards sustainable resource recovery.

The unique properties of nanomaterials offer vast opportunities to advance sustainable processes. Incidental nanoparticles (INPs) represent a significant part of nanomaterials, yet their potential for sustainable applications remains largely untapped. Herein, we developed a simple strategy to harness INPs to upgrade the waste-to-resource paradigm, significantly reducing the energy consumption and greenhouse gas emissions.

Moisture-based green energy harvesting over 600 hours via photocatalysis-enhanced hydrovoltaic effect.

Harvesting the energy from the interaction between hygroscopic materials and atmospheric water can generate green and clean energy. However, the ion diffusion process of moisture-induced dissociation leads to the disappearance of the ion concentration gradient gradually, and there is still a lack of moisture-based power generation devices with truly continuous operation, especially the duration of the current output still needs to be extended. Here, we propose a design for reconstructing the ion concentration gradient by coupling photocatalytic hydrogen evolution reaction with hydrovoltaic effect, to report a moisture-enabled electric generator (MEG) with continuous current output.

Structural and electronic features enabling delocalized charge-carriers in CuSbSe.

Inorganic semiconductors based on heavy pnictogen cations (Sb and Bi) have gained significant attention as potential nontoxic and stable alternatives to lead-halide perovskites for solar cell applications. A limitation of these novel materials, which is being increasingly commonly found, is carrier localization, which substantially reduces mobilities and diffusion lengths. Herein, CuSbSe is investigated and discovered to have delocalized free carriers, as shown through optical pump terahertz probe spectroscopy and temperature-dependent mobility measurements.

A flexible catheter-based sensor array for upper airway soft tissues pressure monitoring.

Obstructive sleep apnea is a globally prevalent concern with significant health impacts, especially when coupled with comorbidities. Accurate detection and localization of airway obstructions are crucial for effective diagnosis and treatment, which remains a challenge for traditional sleep monitoring methods. Here, we report a catheter-based flexible pressure sensor array that continuously monitors soft tissue pressure in the upper airway and facilitates at the millimeter level.

STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration.

The role of the immune system in regulating tissue stem cells remains poorly understood, as does the relationship between immune-mediated tissue damage and regeneration. Graft vs. host disease (GVHD) occurring after allogeneic bone marrow transplantation (allo-BMT) involves immune-mediated damage to the intestinal epithelium and its stem cell compartment.

Elucidating Manganese Single-Atom Doping: Strategies for Fluorescence Enhancement in Water-Soluble Red-Emitting Carbon Dots and Applications for FL/MR Dual Mode Imaging.

The absence of the enhancement of fluorescence in carbon dots (CDs) through doping with transition metal atoms (TMAs) hinders the advancement of multi-modal bio-imaging CDs with high photoluminescence quantum yield (PLQY). Herein, Mn-atomically-doped R-CDs (R-Mn-CDs) with a high PLQY of 41.3% in water is presented, enabling efficient in vivo dual-mode fluorescence/magnetic resonance (MR) imaging.

Mendelian randomization analysis of blood uric acid and risk of preeclampsia: based on GWAS and eQTL data.

Background: The causal association between blood uric acid and preeclampsia (Preeclampsia, PE) has not been conclusively established based on the literature reviewed to date. This bi-directional Mendelian randomization study aimed to investigate the bi-directional causal association between blood uric acid concentration and PE at different genetic levels.

Methods: Pooled data on preeclampsia (sample size = 82,085) and blood uric acid (sample size = 129,405) were conducted based on publicly available genome-wide association analysis (Genome-Wide Association Study, GWAS) on the East Asian populations regarding preeclampsia and blood uric acid, respectively.

Food Safety Evaluation of Recombinant Humanized Type III Collagen Produced by Komagataella phaffii SMD1168-2COL3.

Collagens are biofunctional proteins that have been widely used in many fields, including biomedical, cosmetics, and skin care for their value in maintaining the integrity of cellular membranes. Collagens are also commonly consumed in foods and provide a source of protein and amino acids. As part of the safety assessment for this particular recombinant humanized type III (RHTypeIII) collagen produced by Komagataella phaffii SMD1168-2COL3, a series of toxicological tests were conducted.

LINC02987 suppression hepatocellular carcinoma progression by modulating autophagy via the miR-338-3p/ATG12 axis.

Hepatocellular carcinoma (HCC), the most common primary liver cancer, is marked by a high mortality rate, with the misregulation of long non-coding RNAs (LncRNAs) playing a key role in its development. Here, we studied the role of LINC02987 in HCC. We employed bioinformatics tools to identify LncRNAs and miRNAs that exhibit differential expression in HCC.

Dihydromyricetin/montmorillonite intercalation compounds ameliorates DSS-induced colitis: Role of intestinal epithelial barrier, NLRP3 inflammasome pathway and gut microbiota.

Dihydromyricetin (DHM), the primary active compound in vine tea possesses various pharmacological effects such as anti-inflammatory and antioxidant properties, along with high biosafety. However, its oral delivery remains a significant challenge. Montmorillonite (MMT), the primary component of bentonite, is a commonly used drug in the clinical treatment of gastrointestinal diseases and serves as an excellent drug carrier due to its intercalation capability.

Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy.

Gastric cancer (GC) is a highly aggressive and heterogeneous malignancy. The process of ferroptosis regulates tumor growth and represents a promising therapeutic target for GCs. Despite Salidroside (Sal) being able to regulate ferroptosis in a variety of diseases, there are still limited reports on its therapeutic effects and potential targets in treating GC.

Phycocyanin hexamers and their associated linker polypeptides in phycobilisomes from the marine red alga Polysiphonia urceolata.

Pure phycocyanin (PC) hexamers from red algae were first prepared in this research. PC hexamers are helpful for studying the role and mechanism of PCs in energy transfer within phycobilisomes from red algae. The PC hexamers from Polysiphonia urceolata are stable at lower pH (pH 5.

Robotic total knee arthroplasty safely reduces length of stay in an Asian public healthcare system.

Aims: Around the world, the emergence of robotic technology has improved surgical precision and accuracy in total knee arthroplasty (TKA). This territory-wide study compares the results of various robotic TKA (R-TKA) systems with those of conventional TKA (C-TKA) and computer-navigated TKA (N-TKA).

Methods: This is a retrospective study utilizing territory-wide data from the Clinical Data Analysis and Reporting System (CDARS).

QTypeMix: Enhancing multi-agent cooperative strategies through heterogeneous and homogeneous value decomposition.

In multi-agent cooperative tasks, the presence of heterogeneous agents is familiar. Compared to cooperation among homogeneous agents, collaboration requires considering the best-suited sub-tasks for each agent. However, the operation of multi-agent systems often involves a large amount of complex interaction information, making it more challenging to learn heterogeneous strategies.

The effect of anti-pronation and anti-supination taping on neuromuscular control in recreational athletes with Achilles Tendinopathy: A randomized controlled cross-over trial.

Objectives: To investigate the effects of different directions of athletic taping on neuromuscular control of the lower limb in recreational athletes with Achilles tendinopathy (AT).

Design: Crossover Study.

Setting: Functional assessment laboratory.