Publications by authors named "Xiao-bing Yang"

Accumulating evidence are available on the efficacy of high-dose isoniazid (INH) for multidrug-resistant tuberculosis (MDR-TB) treatment. We aimed to perform a systematic review and meta-analysis to compare clinical efficacy and safety outcomes of high-dose INH- containing therapy against other regimes. We searched the following databases PubMed, Embase, Scopus, Web of Science, CINAHL, the Cochrane Library, and ClinicalTrials.

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Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pancreatitis (CP). Here, we investigated whether efferocytosis constitutes a novel regulatory target in CP and its mechanisms. PRSS1 transgenic (PRSS1) mice were treated with caerulein to mimic CP development.

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The medium-chain fatty acid ethyl esters (MCFAEEs) are a group of important aroma compounds generated during wine production. Wine alcohol fermentation involves several redox processes, which are affected by the oxidation-reduction potential (ORP). However, the mechanism via which ORP regulates MCFAEE production remains unclear.

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Article Synopsis
  • The study investigates St13, a co-chaperone protein, as a potential target for early diagnosis and treatment of chronic pancreatitis (CP), while also assessing micro-PET/CT for diagnosing CP in its early stages.
  • Analysis included data from healthy individuals and patients with different types of CP, along with experiments on genetically modified mice, revealing that the arachidonic acid pathway is significantly disrupted in CP cases.
  • Findings suggest that St13 protects against CP by stabilizing critical signaling pathways, and that Ga-FAPI-04 micro-PET/CT can effectively evaluate pancreatic conditions, offering new insights into CP diagnosis and treatment.
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Background: Wuhan was the first epicentre of COVID-19 in the world, accounting for 80% of cases in China during the first wave. We aimed to assess household transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and risk factors associated with infectivity and susceptibility to infection in Wuhan.

Methods: This retrospective cohort study included the households of all laboratory-confirmed or clinically confirmed COVID-19 cases and laboratory-confirmed asymptomatic SARS-CoV-2 infections identified by the Wuhan Center for Disease Control and Prevention between Dec 2, 2019, and April 18, 2020.

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Scientific communication is facilitated by a data-driven, scientifically sound taxonomy that considers the end-user's needs and established successful practice. In 2013, the community voiced near unanimous support for a concept of that represented a clade comprising all agriculturally and clinically important species, including the species complex (FSSC). Subsequently, this concept was challenged in 2015 by one research group who proposed dividing the genus into seven genera, including the FSSC described as members of the genus , with subsequent justification in 2018 based on claims that the 2013 concept of is polyphyletic.

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There is no curative therapy for severe acute pancreatitis (SAP) due to poor understanding of its molecular mechanisms. Endoplasmic reticulum (ER) stress is involved in SAP and increased expression of ATF6 has been detected in SAP patients. Here, we aimed to investigate the role of ATF6 in a preclinical SAP mouse model and characterize its regulatory mechanism.

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Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, Hubei Province, China in late December 2019. We re-analysed 640 throat swabs collected from patients in Wuhan with influenza-like-illness from 6 October 2019 to 21 January 2020 and found that 9 of the 640 throat swabs were positive for SARS-CoV-2 RNA by quantitative PCR, suggesting community transmission of SARS-CoV2 in Wuhan in early January 2020.

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Objective: To observe the effect of hypnosis on pain and fear in the healthy acupuncture subjects.

Methods: A total of 52 healthy subjects were randomized into an observation group and a control group, 26 cases in each one. In the observation group, the subjects received the first-time acupuncture under hypnosis.

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A novel composite vanadium-blocking proton exchange membrane for vanadium redox flow battery (VRB) was designed and constructed by immobilizing phosphotungstic acid (PWA) on Nano Kevlar Fibers (NKFs) via a solution-casting method. The proton/vanadium selectivity of the composite membrane is greatly improved by incorporating the complex formed by NKFs and PWA into the Nafion matrix. Simple tuning of the complex doping quantity results in different composite membranes with superior vanadium barrier properties (namely, a minimum vanadium permeability of 2.

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Hand-foot-mouth disease (HFMD) is a serious public health problem with increasing cases and substantial financial burden in China, especially in Wuhan city. Hence, there is an urgent need to construct a model to predict the incidence of HFMD that could make the prevention and control of this disease more effective.The incidence data of HFMD of Wuhan city from January 2009 to December 2016 were used to fit a combined model with seasonal autoregressive integrated moving average (SARIMA) model and support vector regression (SVR) model.

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Article Synopsis
  • * Researchers developed a seasonal ARIMA model to analyze 84 months of HFMD data (2009-2015) for forecasting future incidences, which showed effective predictions with clear pattern recognition.
  • * The identified optimal ARIMA model (1,0,1)(0,1,1) demonstrated strong predictive capabilities, highlighting two peaks of HFMD activity in mid-year and late-year, and emphasizes the need for continual updates to the model for improved future forecasts.
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  • This study investigates the potential of long non-coding RNAs (lncRNAs) in peripheral blood as non-invasive biomarkers for acute rejection (AR) in kidney transplants.
  • Researchers analyzed lncRNA expression profiles in 150 blood samples from both pediatric and adult transplant recipients to identify differences between those experiencing AR and those who are not.
  • They identified 23 lncRNAs common to both groups that could effectively distinguish AR cases, and created a risk score using two significant lncRNAs that showed strong diagnostic performance, making them promising candidates for AR detection in kidney transplant patients.
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  • Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults, and this study focused on analyzing microRNA (miRNA) expression profiles to distinguish between tumors with mutant and wild-type mutation statuses.
  • The researchers identified 33 differentially expressed miRNAs, 11 of which were significantly associated with overall survival in patients with wild-type status, contributing to a newly developed mutation-specific miRNA signature.
  • This miRNA signature, involving 11 key miRNAs, has the potential to act as a new prognostic biomarker for ccRCC patients, potentially aiding in patient management and treatment strategies.
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Article Synopsis
  • - The study aimed to assess the combined effect of Fuzheng Kang'ai Formula (FZKA) and gefitinib on patients with advanced non-small cell lung cancer who have EGFR mutations, through a randomized controlled trial involving 70 treatment-naive participants.
  • - Results showed that the group receiving the combined treatment (FZKA plus gefitinib) had significantly longer progression-free survival (PFS) and median survival time (MST) compared to those taking gefitinib alone, with median PFS of 12.5 months versus 8.4 months.
  • - Both treatment groups had similar rates of overall response and disease control; however, the combination treatment resulted in less severe toxicities, making it
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Background: Although several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early prediction of AKI in acute decompensated heart failure patients.

Methods And Results: A total of 676 consecutive acute decompensated heart failure participants were prospectively enrolled from 6 regional central hospitals.

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Objective To observe the effect of Fuzheng Kang'ai Recipe (FKR) combined ge- fitinib on the proliferation and apoptosis of lung cancer A549 cells , and to study its potential synergistic mechanish with gefitinib. Methods The effects of FKR (0. 211, 0.

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Purpose: Excessive ST3Gal-I levels predict a poor outcome for patients with several types of tumors. This study aims to investigate the role of ST3Gal-I in determining the invasive and metastatic potential of human hepatocellular carcinoma (HCC) and clinical prognosis for patients with HCC.

Methods: We compared the expression of ST3Gal-I in various HCC cell lines and in 20 pairs of tumor and peritumor tissue samples using Western blot analysis.

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Objective: To investigate the impact of impoundment and active public health interventions on rodent populations and rodent-borne diseases in the Three Gorges reservoir region from 1997 to 2012.

Methods: Surveillance data from 1997 to 2012 were extracted from the Public Health Surveillance System of The Three Gorges established in 1997. Temporal changes in the incidences of hemorrhagic fever with renal syndrome (HFRS) and leptospirosis, rodent density, pathogen-carrying rates, and their correlations were analyzed.

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Objective: To evaluate the clinical efficacy of Jianpi Liqi Yiliu Formula (JLYF) combined with cytokine-induced killer (CIK) cells for treating patients with advanced hepatocellular carcinoma (HCC).

Methods: Between January 2011 and January 2014, 60 advanced HCC patients were enrolled in this study, who were assigned to the treatment group and the control group according to their willingness for taking JLYF, 30 cases in each group. All patients received CIK cell treatment: 1 x 10⁹-3 x 10⁹ each time, by intravenous dripping from the 1st day to the 3rd day, once per day.

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To optimize Agrobacterium-mediated transient transformation assay in mulberry (Morus alba L.), various infiltration methods, Agrobacterium tumefaciens (A. tumefaciens) strains, and bacterial concentrations were tested in mulberry seedlings.

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Bladder cancer ranks the second most common genitourinary tract cancer, and muscle-invasive bladder cancer (MIBC) accounts for approximately 25 % of all bladder cancer cases with high mortality. In the current study, with a total of 202 treatment-naïve primary MIBC patients identified from The Cancer Genome Atlas dataset, we comprehensively analyzed the genome-wide microRNA (miRNA) expression profiles in MIBC, with the aim to investigate the relationship of miRNA expression with the progression and prognosis of MIBC, and generate a miRNA signature of prognostic capabilities. In the progression-related miRNA profiles, a total of 47, 16, 3, and 84 miRNAs were selected for pathologic T, N, M, and histologic grade, respectively.

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Background: Patients with advanced non-small cell lung cancer (NSCLC) harboring mutations of the epidermal growth factor receptor (EGFR) gene respond well to the EGFR tyrosine kinase inhibitor (TKI) gefitinib. Chinese herbal medicine (CHM) has been used as a complementary therapy for cancer for decades in China. CHM was proved to be effective in improving the quality of life (QOL) and reducing the toxicity associated with chemotherapy in patients with NSCLC.

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Background: Some patients with non-small-cell lung cancer (NSCLC) respond well to the EGFR tyrosine kinase inhibitor gefitinib. Chinese herbal medicine (CHM) was effective in improving the quality of life and prolonging overall survival in patient with NSCLC. We aim to determine whether gefitinib plus CHM could prolong the progression-free survival (PFS) or median survival time (MST) in patients with NSCLC than gefitinib alone.

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