Publications by authors named "Xiao-Zi Wang"
High level of tumor-infiltrating lymphocytes (TILs) can predict the rate of total pathological complete remission (tpCR) of breast cancer patients who receive neoadjuvant chemotherapy (NACT). This study focused on evaluating the data of patients whose primary tumor and/or lymph node metastasis show nonresponse (NR) to NACT, trying to provide a basis for the clinical decision which patients will develop NACT resistance. The study included breast cancers from 991 patients who received NACT.
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- Triple-negative breast cancer (TNBC) is aggressive and lacks effective treatments, but PD-L1 inhibitors have been recently approved, prompting research on the involvement of ATM in regulating PD-L1 and patient prognosis.
- 86 TNBC samples were analyzed to uncover relationships between ATM, c-Src, STAT1, STAT3, PD-L1, and tumor-infiltrating lymphocytes (TILs), revealing that low ATM expression is linked to poor outcomes and a distinctive role of STAT3 in prognosis.
- The study suggests that TNBC patients with low ATM may benefit from anti-PD-L1 treatment and highlights the potential of combining ATM inhibitors with immune therapies, indicating that STAT3 influences tumor progression variably across different cancers.
Pulmonary tuberculosis presenting as henoch-schönlein purpura: Case report and literature review.
Medicine (Baltimore)
October 2020
Introduction: Henoch-Schönlein purpura (HSP) is an extremely rare condition in patients with pulmonary tuberculosis, with only a few reported cases. Compared to patients with typical clinical symptoms, it is difficult to make a definitive diagnosis when HSP presents as an initial manifestation in pulmonary tuberculosis patients. Herein, a case of pulmonary tuberculosis that showed HSP at first was reported, and the related literatures were reviewed.
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