Publications by authors named "Xiao-Zhuo Chen"
A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial.
View Article and Find Full Text PDFA new series of macrolide derivatives with 4''-O-saccharide substituents.
Bioorg Med Chem Lett
September 2010
Article Synopsis
- A new type of macrolide derivatives with 4''-O-mono- or disaccharides was created using glycosyl trichloroacetimidates for glycosylation.
- Tests were conducted to evaluate the antibacterial effectiveness of these derivatives against both susceptible and resistant bacterial pathogens.
- This research aims to enhance our understanding of how these modified macrolides interact with bacterial ribosomes, potentially leading to better antibacterial treatments.
Article Synopsis
- Researchers have developed a new series of 14-membered macrolides with unique imidazo[4,5-b]pyridinyl sulfur side chains based on clarithromycin.
- The chemical transformation of the hydroxy group at position C-3 led to the creation of various ketolides and acylides.
- One particular compound, 15a, showed enhanced effectiveness in lab tests against both erythromycin-sensitive and resistant bacteria compared to telithromycin.