Publications by authors named "Xiao-Zhuan Liang"
Article Synopsis
- - The study explores how double-strand breaks (DSBs) created by Cas9 in the retrotransposon Ty1 in yeast can lead to significant genomic changes, such as deletions and rearrangements of chromosomes.
- - Researchers found that most of these rearrangements occurred through non-allelic homologous recombination at Ty1 elements, showing that certain Ty clusters are hotspots for these genetic changes.
- - The results indicate differences in repair pathways used by haploid and diploid yeast strains, underscoring the role of retrotransposons in genome evolution through DNA damage and repair mechanisms.
Global Analysis of Furfural-Induced Genomic Instability Using a Yeast Model.
Appl Environ Microbiol
September 2019
Furfural is an important renewable precursor for multiple commercial chemicals and fuels; a main inhibitor existing in cellulosic hydrolysate, which is used for bioethanol fermentation; and a potential carcinogen, as well. Using a genetic system in that allows detection of crossover events, we observed that the frequency of mitotic recombination was elevated by 1.5- to 40-fold when cells were treated with 0.
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