Publications by authors named "Xiao-Zhi Zhan"
Article Synopsis
- SBDS outbreaks caused by NGPV have been noted in China since 2015, with NGPV being a single-stranded DNA virus likely transmitted vertically.
- The study found that NGPV boosts cGAS mRNA expression but weakens the induction of IFN-β, inhibiting downstream interferon-stimulated genes and interfering with the immune response.
- VP1, a viral protein, plays a crucial role in inhibiting IFN-β expression, while its truncated forms lack this capability, indicating that NGPV impacts the host's innate immune response through modulation involving IRF7.
In poultry reproduction, the decline of ovarian function due to aging is related to dysfunction of mitochondria exacerbated by a reduction in antioxidant capacity, ultimately leading to follicle atresia and decreased egg production. However, the mechanisms of mitochondrial dysfunction in the chicken ovary in aging have remained to be understood. Hence, this study aims to investigate the effects of aging on mitochondrial function and cellular homeostasis.
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- * High concentrations of LPS downregulate specific genes related to cell proliferation and steroid hormone synthesis, while also increasing p27kip1 expression, indicating cell cycle alterations.
- * Elevated temperatures further worsen LPS's inhibitory effects on gene expression related to proliferation and steroid hormone production, highlighting a complex interaction between heat and LPS in duck GCs.