Publications by authors named "Xiao-Zhen Kang"
Article Synopsis
- The HBV X protein (HBx) binds to anti-apoptotic proteins Bcl-2 and Bcl-xL, which helps the virus replicate and can cause cell damage.
- Researchers identified the crystal structure of HBx's binding motif interacting with Bcl-xL, revealing specific residues critical for this interaction.
- Mutations in key residues weaken HBx's ability to bind Bcl-xL and reduce HBV replication, indicating that understanding this interaction is key for developing therapies to inhibit HBV.
Objective: This study aimed to develop a novel therapeutic vaccine based on a unique B cell epitope and investigate its therapeutic potential against chronic hepatitis B (CHB) in animal models.
Methods: A series of peptides and carrier proteins were evaluated in HBV-tolerant mice to obtain an optimised therapeutic molecule. The immunogenicity, therapeutic efficacy and mechanism of the candidate were investigated systematically.
[Outcome after surgery preserving pharynx and larynx for cervical esophageal cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
January 2012
Objective: To evaluate the long-term survival of multidisciplinary treatment based on thoracic surgery for cervical esophageal squamous cell carcinoma.
Methods: The clinical characters and follow-up data of forty-one cervical esophageal cancer patients who accepted multidisciplinary treatment based on surgery with preservation of pharynx and larynx were retrospectively reviewed, and the long-term survival was compared with 480 non-cervical esophageal cancers who accepted surgery in the same period done by the same surgical team.
Results: There were 28 males and 13 females with a mean age of 62 years old.