I Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats.

Intracellular Ca overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (I) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of I currents is a compensation for I deficit and a novel modulation for cardiac Ca homeostasis and pathological remodeling. In adult Sprague-Dawley (SD) rats , cardiac hypertrophy was induced by isoproterenol (Iso) injection (i.