Publications by authors named "Xiao-Yun Min"
Article Synopsis
- The urinary tract normally faces many germs, and our bodies have ways to fight them off, especially in the kidneys.
- Researchers found that a special protein called CL-11, made in the kidneys, is super important for defending against infections in the kidneys and bladder.
- When there wasn't enough CL-11, mice got worse infections, but giving them more CL-11 helped reduce the infections, which shows it could help people too!
Article Synopsis
- CL-11 is a new protein that helps in developing embryos, fighting infections, and dealing with diseases like cancer.
- Researchers found that when they removed CL-11 from mice, melanoma (a type of skin cancer) grew slower, showing that CL-11 helps cancer cells grow faster.
- High levels of the COLEC11 gene in human cancers are linked to worse survival, which indicates that targeting CL-11 could be a potential way to treat tumors.
CD3CD56NKT-like cells are a rare population of lymphocytes that serve important roles in various types of immune-related diseases, and particularly in cancer. The complement system regulates inflammatory and immune responses by interacting with complement receptors expressed on a range of immune cells. However, whether CD3CD56NKT-like cells are regulated by the complement system has still not been definitively determined.
View Article and Find Full Text PDFComplement receptor 3 (CR3) is expressed abundantly on natural killer (NK) cells; however, whether it plays roles in NK cell-dependent tumor surveillance is largely unknown. Here, we show that CR3 is an important negative regulator of NK cell function, which has negative impact on tumor surveillance. Mice deficient in CR3 (CD11b mice) exhibited a more activated NK phenotype and had enhanced NK-dependent tumor killing.
View Article and Find Full Text PDFObjective: Recent reports have shown that C-X-C chemokine receptor 4 (CXCR4) is expressed in ovarian cancer and plays an important role in metastasis. However, the prognostic value of CXCR4 in ovarian cancer remains controversial and has not been emphasized. The aim of this study is to evaluate the prognostic significance of CXCR4 in ovarian cancer by performing a meta-analysis.
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