Publications by authors named "Xiao-Yue Qiu"
Article Synopsis
- The study investigates how the hormone 17β-estradiol affects TASK-1 expression in nerve cells (N2A), revealing potential neuroprotective effects.
- Knockdown experiments show that estrogen receptor β (ERβ) is the specific receptor that interacts with 17β-estradiol, rather than estrogen receptor α.
- The findings indicate that the neuroprotective actions of estrogen are likely mediated through ERβ, suggesting a role for TASK-1 channels in promoting cell proliferation.
Background: Voltage-gated K(+) (Kv) channels have a pivotal role in tuning the action potential duration and excitability in neuronal cells. Although Ca(2+) channel antagonist nifedipine exhibited an inhibitory effect on cardiac Kv currents, a possible action of nifedipine on neuronal Kv currents has not been fully investigated.
Methods: The effects of nifedipine on elicited Kv currents were characterized using whole-cell recording in mouse neuroblastoma N2A cells.
It is well documented that nifedipine, a commonly used dihydropyridine Ca2+ channel blocker, has also significant interactions with voltage-gated K+ (Kv) channels. But to date, little is known whether nifedipine exerted an action on Kv2.1 channels, a member of the Shab subfamily with slow inactivation.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how estrogen (specifically 17β-estradiol) affects large-conductance Ca(2+)-activated K(+) (BK) channels in mouse N2A and human SK-N-SH cells.
- Results showed that exposure to 17β-estradiol increased the mRNA levels of BK channel subunits in a dose-dependent manner, with prolonged exposure enhancing the effect further.
- The role of estrogen receptors was highlighted, showing that silencing ERβ diminished the effects of estrogen on BK channels, pointing to ERβ's critical involvement in this regulatory mechanism.