Publications by authors named "Xiao-Yue Cao"
Decreased expression of HDAC8 indicates poor prognosis in patients with intrahepatic cholangiocarcinoma.
Hepatobiliary Pancreat Dis Int
October 2019
Background: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant primary tumor in the liver, and the rates of incidence and mortality are rapidly increasing globally. Histone deacetylase 8 (HDAC8) is a transcriptional regulator and is associated with tumorigenesis of several tumor types. This study aimed to evaluate the correlation between HDAC8 expression and clinicopathological parameters in ICC patients.
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- HDAC3 is crucial for liver regeneration and cell cycle regulation, as its absence severely impairs hepatocyte proliferation.
- Research shows that HDAC3 influences the STAT3 signaling pathway, specifically disrupting the transition from ac-STAT3 to p-STAT3, which is essential for cell growth.
- Overexpression of HDAC3 is linked to increased tumor growth and poor prognosis in hepatocellular carcinoma (HCC), indicating its role as a potential therapeutic target.
Elevated expression of Gα in intrahepatic cholangiocarcinoma associates with poor prognosis.
Hepatobiliary Pancreat Dis Int
December 2017
Background: The stimulatory G protein a subunit (Gα) plays important roles in diverse cell processes including tumorigenesis. Activating mutations in Gα gene (GNAS) have been reported to be associated with poor prognosis in various human carcinomas. Furthermore, Gα signaling is crucial in promoting liver regeneration by interacting with growth factor signaling, indicating that Gα might play a promoting role in cancer development.
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