Publications by authors named "Xiao-Yi Mai"
The triglyceride-glucose (TyG) index, a reliable surrogate biomarker of insulin resistance (IR), is highlighted recently as related to cardiac disorders. However, the associations of the TyG index and its combination with blood pressure (BP) on cardiovascular and all-cause mortality in hypertension remain unclear. In this study, we included 9,635 hypertension patients from the National Health and Nutrition Examination Survey 1999-2018.
View Article and Find Full Text PDFArticle Synopsis
- Some research shows that HbA1c levels, which reflect blood sugar over the last 2-3 months, might relate to heart problems like heart failure.
- The study aims to find out how HbA1c levels affect the chances of dying or going back to the hospital for heart failure patients.
- They will look at various research sources to see if there's a clear connection and will consider many factors like different types of heart failure and if patients have diabetes or not.
Systemic inflammation markers have been highlighted recently as related to cardiac and non-cardiac disorders. However, few studies have estimated pre-diagnostic associations between these markers and hypertension. In the National Health and Nutritional Examination Survey from 1999 to 2010, 22,290 adult participants were included for analysis.
View Article and Find Full Text PDFBackground: Leisure-time moderate-to-vigorous physical activity (MV-PA) has been consistently regarded as a protective factor to prevent and treat hypertension. However, the effect of different levels of MV-PA against cardiocerebrovascular and all-cause mortality in hypertension is still unclear. The aim of this study was to explore the dose relationships of MV-PA on these adverse outcomes in hypertension.
View Article and Find Full Text PDFIncreasing evidence supports that activation of store-operated Ca entry (SOCE) is implicated in the chemoresistance of cancer cells subjected to chemotherapy. However, the molecular mechanisms underlying chemoresistance are not well understood. In this study, we aim to investigate whether 5-FU induces hepatocarcinoma cell death through regulating Ca -dependent autophagy.
View Article and Find Full Text PDFInhibition of Orai1 Store-Operated Calcium Channel Prevents Foam Cell Formation and Atherosclerosis.
Arterioscler Thromb Vasc Biol
April 2016
Objective: To determine the role of orai1 store-operated Ca(2+) entry in foam cell formation and atherogenesis.
Approach And Results: Acute administration of oxidized low-density lipoprotein (oxLDL) activates an orai1-dependent Ca(2+) entry in macrophages. Chelation of intracellular Ca(2+), inhibition of orai1 store-operated Ca(2+) entry, or knockdown of orai1 dramatically inhibited oxLDL-induced upregulation of scavenger receptor A, uptake of modified LDL, and foam cell formation.
Background: Previous work has demonstrated that the volume-regulated chloride channel is activated during foam cell formation, and inhibition of chloride movement prevents intracellular lipid accumulation. However, the mechanism explaining how chloride movement promotes foam cell formation is not clear.
Methods and results: Foam cell formation was determined by Oil Red O staining.