Decatungstate-Photocatalyzed Transformations of 2-Bromo-3,3,3-trifluoropropene for Selective Synthesis of /-β-CF-Enones.

Condition-controlled switchable and divergent transformations of cost-effective 2-bromo-3,3,3-trifluoropropene (BTP) and aldehydes were realized using a decatungstate (TBADT)-photocatalyzed strategy. The hydroacylated products, i.e.

Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1.

The development of targeted chemotherapeutic agents against colorectal cancer (CRC), one of the most common cancers with a high mortality rate, is in a constant need. Nannocystins are a family of myxobacterial secondary metabolites featuring a 21-membered depsipeptide ring. The in vitro anti-CRC activity of natural and synthetic nannocystins was well documented, but little is known about their in vivo efficacy and if positive, the underlying mechanism of action.

Acyl Radicals from α-Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles.

A general and metal-free visible-light-induced decarboxylative arylation procedure at room temperature was described for the construction of acylated heterocyclic derivatives, such as benzimidazo/indolo[2,1-]isoquinolin-6(5)-ones, aroylazaspiro[4.5]trienones, thioflavones, and so on. This practical arylation procedure was conducted by using 2,4,5,6-tetra(9-carbazol-9-yl)isophthalonitrile (4CzIPN) as a photocatalyst under mild conditions, which avoided the use of an additional base, traditional heating, and metal reagents.

[Pollution by heavy metals in the petrochemical sewage waters of the sea area of Daya Bay and assessment on potential ecological risks].

This study aimed to gain a clear understanding on the status of pollution by heavy metals in the petrochemical sewage and the potential ecological risk caused by heavy metal pollution in the sea area of Daya Bay. The contents and spatial distributions of heavy metals including Zn, Pb, Cu, Cd, Cr, As and Hg in seawater, sediment and fishes collected from Daya Bay were analyzed. The comprehensive pollution index (CPI) and ecological risk indexes (ERIs) were used to evaluate the contaminated severity and potential ecological risks of heavy metals in seawater and sediment.