Publications by authors named "Xiao-Ya Qi"
SARS-CoV-2 continues to mutate, spread, and impact public health and daily life. The main protease (M) is essential for the replication and maturation of SARS-CoV-2, making it an ideal target for anti-coronaviral drug discovery and development due to its high conservation and lack of homologous proteases in humans. Herein, we designed and synthesized a series of dithiocarbamate derivatives as potent SARS-CoV-2 M inhibitors.
View Article and Find Full Text PDFThe COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The main protease (M) stands as an essential enzyme in the maturation process of SARS-CoV-2, playing an irreplaceable role in regulating viral RNA replication and transcription. It has emerged as an ideal target for developing antiviral agents against SARS-CoV-2 due to its high conservation and the absence of homologous proteases in the human body.
View Article and Find Full Text PDFObjective: To assess the effect of a novel naturally cultured rice with high resistant starch (RS) on postprandial glycemia in patients with type 2 diabetes compared to ordinary rice.
Design: This study is a randomized, double-blinded controlled trial.
Methods: Patients with type 2 diabetes were recruited, and postprandial glucose levels were measured at 5-time points after the ingestion of one of two types of cooked rice in random order.
Article Synopsis
- * The synthesized compounds showed varying levels of effectiveness against wild-type HIV-1, with some exhibiting strong potency and selectivity as reverse transcriptase inhibitors, especially compound 4d, which was particularly effective against both wild-type and several mutant strains of HIV-1.
- * Additional analyses included assessing the structure-activity relationships of the compounds, performing molecular modeling to investigate how DPAPYs bind to HIV-1 reverse transcriptase, and predicting their
Wearable physical activity trackers are getting popular for the self-management of weight despite limited evidence of their efficacy. Studies have proven that on-site supervised exercise is superior to unsupervised exercise for many health problems, there is no evidence comparing the effectiveness of remote supervision exercise with self-directed exercise based on mHealth. This study aims to compare the effects of mHealth-based supervised exercise to mHealth-based self-directed exercise on weight control in the overweight and obese population.
View Article and Find Full Text PDFThe influx of COVID-19 infection and government-enforced lockdowns and social isolation changed people's lifestyles. Concerns regarding the health impact of the COVID-19 pandemic due to the new sedentary lifestyle. This study aims to investigate the impact of the COVID-19 pandemic on cardiovascular health factors.
View Article and Find Full Text PDFObjective: To investigate the effects of visfatin gene overexpression on insulin sensitivity in insulin-resistant (IR) rats induced by high-fat diet.
Methods: The recombinant visfatin plasmid was constructed and transfected into IR rats induced by high-fat diet. The euglycemic-hyperinsulinemic clamp experiments were performed for evaluation the change of insulin sensitivity before and after administration.