Publications by authors named "Xiao-Ya Jin"
Gold nanoparticles (AuNPs) in aggregated state have a strong near infrared region (NIR) absorption and the causes a much stronger photothermal effect than that of the dispersed AuNPs. Strand-displacement amplification (SDA) can produce large amount of single-stranded DNA (ssDNA), which in turn effectively prevent AuNPs from aggregation. In this study, these characteristics had been applied to design a photothermal biosensor for human papilloma virus (HPV and HPV16 were chosen as model target) detection.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNA-223-3p (miR-223-3p) has potential in reducing inflammation and is found in exosomes from bone mesenchymal stem cells (MSC-exosomes), which can transport microRNAs into cells.
- MSC-exosomes were tested for their ability to deliver miR-223-3p to macrophages in the context of autoimmune hepatitis and were shown to be non-toxic.
- The study found that treatment with MSC-exosomes alone or with miR-223-3p reduced inflammation in the liver and cytokine release, indicating a possible therapeutic use of MSC-exosomes to deliver miR-223-3p for treating autoimmune hepatitis.
Autoimmune hepatitis (AIH) is chronic autoimmune liver disease accompanied with the imbalance of Treg/Th17 and increased intestinal permeability. We investigated the effects of a high fiber diet and sodium butyrate on the Treg/Th17 and intestinal barrier function in an experimental autoimmune hepatitis. Intraperitoneal injection of hepatic antigen (S100) was used to induce experimental autoimmune hepatitis mice model and mice were divided into normal control, S100 model control, S100 plus high fiber diet and S100 plus sodium butyrate.
View Article and Find Full Text PDFAutoimmune hepatitis is a chronic inflammatory disease in the liver with potential to the development of liver fibrosis. Recent evidences suggest that bone marrow derived mesenchymal stem cells (BMSCs) may exert its therapeutic activity through exosomes. Moreover, miR-223 is highly expressed in BMSCs and plays an important role in autoimmune diseases.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies show that an imbalance in gut bacteria and a leakiness in the intestinal barrier may trigger autoimmune hepatitis, and sodium butyrate supplementation could help protect the liver.
- In an experiment, C57BL/6 mice were divided into three groups: a control, an autoimmune hepatitis group, and a group receiving sodium butyrate treatment to assess its effectiveness.
- Results indicated that sodium butyrate not only reduced liver damage and intestinal injury but also prevented harmful bacteria from migrating to the liver, likely by inhibiting certain inflammatory pathways.