Factors contributing to diagnostic delay of Caroli syndrome: a single-center, retrospective study.

Background: Caroli syndrome (CS) is a rare congenital disorder without pathognomonic clinical symptoms or laboratory findings; therefore, the diagnosis is often delayed. The objective of this study was to investigate the diagnostic delay and associated risk factors in CS patients.

Methods: This was a retrospective analysis of 16 CS patients admitted to a single tertiary medical center on mainland China.

Activation of the kinin system in the ovary during ovulation: role of endogenous progesterone.

Background: Previous work by our group and others has implicated a role for kinins in the ovulatory process. The purpose of the present study was to elucidate whether endogenous progesterone, which is an intraovarian regulator of ovulation, might be responsible for induction of the kinin system in the ovary during ovulation. The gonadotropin-primed immature rat was used as the experimental model, and the role of endogenous progesterone was explored using the antiprogestin, RU486.