Publications by authors named "Xiao-Xia Gong"
Naked cuticle inhibits wingless signaling in Drosophila wing development.
Biochem Biophys Res Commun
October 2021
Wnt signaling is one of the major signaling pathways that regulate cell differentiation, tissue patterning and stem cell homeostasis and its dysfunction causes many human diseases, such as cancer. It is of tremendous interests to understand how Wnt signaling is regulated in a precise manner both temporally and spatially. Naked cuticle (Nkd) acts as a negative-feedback inhibitor for Wingless (Wg, a fly Wnt) signaling in Drosophila embryonic development.
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- Three new compounds, neo-debromoaplysiatoxin D, oscillatoxin E, and oscillatoxin F, were discovered from a marine cyanobacterium, along with four known analogues.
- The new compounds are classified based on their structural differences: aplysiatoxins have tricyclic ring systems while oscillatoxins have a unique spirobicyclic structure.
- Bioactivity tests revealed that the aplysiatoxins significantly activated a protein kinase, while oscillatoxins displayed strong blocking effects on a potassium channel, with detailed binding analysis highlighting the affinity of oscillatoxin E.
Background: This study was to explore a safe and effective procedure to prevent pancreatic fistula (PF) after pancreaticoduodenectomy (PD).
Methods: Forty-three modified PD with pancreaticojejunostomy by direct invagination of the pancreas to the jejunum that was brought up via the space behind the root of superior mesenteric vessel were performed between January 2003 and June 2006, and were compared to the fifty-six conventional PD (Child' method).
Results: There was no pancreatic fistula after PD in the modified group.