Genetic polymorphism of clopidogrel metabolism related gene gene in Chinese from Foshan area of Guangdong Province.

Background: The gene is highly polymorphic, and is involved in the broad interindividual variability of the clinical efficacy of certain clinical medications, such as clopidogrel. However, data on the genotype in the Chinese population of the Foshan area of Guangdong Province are scarce. The purpose of this study was to determine genetic polymorphisms in patients in the Foshan area and to compare the genotype frequencies in different populations to determine the allele distribution pattern to identify the most appropriate prescription.

Prevalence and genotype distribution of human papillomavirus among 9945 women from the Nanhai area of Foshan.

Background: To provide a scientific basis for the prevention and treatment of cervical cancer (CC), we investigated the distribution characteristics and genotypes of human papillomavirus (HPV) and the prevalence of multiple HPV infections in women of different ages seeking management for abnormal cytology in Foshan City.

Methods: Screening for the 21 genotypes of HPV was carried out in 9945 females seeking management of abnormal cervical cytology results using rapid flow-through hybridization of nucleic acid molecules. The overall prevalence, genotype distribution and age-specific prevalence were examined.

Rapid, accurate detection of TMPRSS6 gene causative mutations with a high-resolution melting assay.

Mutations of the TMPRSS6 gene are considered the major genetic factors for iron-refractory iron deficiency anemia (IRIDA). Artificial clone libraries containing 17 known mutations of the TMPRSS6 gene were used to develop a high-resolution melting (HRM) assay for the detection of 17 TMPRSS6 gene mutations. The melting temperatures and melting curves were able to distinguish the different genotypes of the 17 TMPRSS6 gene mutations.