Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma.

Objective: Although there have been improvements in targeted therapy and immunotherapy, the majority of lung adenocarcinoma (LUAD) patients still lack effective therapies. Consequently, it is urgent to screen for new diagnosis biomarkers and pharmacological targets. Junctional adhesion molecule-like protein (JAML) was considered to be an oncogenic protein and may be a novel therapeutic target in LUAD.

Effects of Ligustrazine on Airway Inflammation in A Mouse Model of Neutrophilic Asthma.

Objective: To investigate the effects of ligustrazine (LTZ) on airway inflammation in a mouse model of neutrophilic asthma (NA).

Methods: Forty healthy C57BL/6 female mice were randomly divided into 4 groups using a random number table, including the normal control, NA, LTZ and dexamethasone (DXM) groups, with 10 rats in each group. The NA mice model was established by the method of ovalbumin combined with lipopolysaccharide sensitization.

[Research on morbidity and relative factors of cough variant asthma among patients with chronic cough syndrome].

Objective: To study the morbidity of cough variant asthma (CVA) among patients with chronic cough syndrome and its relative risk factors.

Methods: Patients were recruited with detailed history on their illness. Data were collected on physical examination, chest X-ray, eosinophil cell counts, pulmonary ventilation with histamine stimulating test and bronchi dilation test.

Effect of ligustrazine injection on levels of interleukin-4 and interferon-gamma in patients with bronchial asthma.

Objective: To explore the effect of ligustrazine injection (LI) on serum levels of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with bronchial asthma and determine the mechanism of action of LI in preventing and treating asthma.

Methods: Sixty-eight patients with mild or moderate bronchial asthma were assigned to two groups equally according to their sequence number, odd or even. The conventional treatment was administered to both groups, and LI was given to the treatment group by ultrasonic spray inhalation twice a day but not to the control group.