Publications by authors named "Xiao-Wei Xi"
Article Synopsis
- The study aimed to assess how hydrogen affects endometrial cancer cells and to identify the molecular mechanisms involved.
- Methods included incubating specific cancer cell lines with hydrogen and using RNA sequencing to analyze gene expressions and signaling pathways related to cancer.
- Results showed that hydrogen treatment activated certain pathways associated with inflammation and cell death, leading to increased rates of apoptosis in the cancer cells, suggesting its potential as a therapeutic target.
Purpose: Stroma-derived factor-1 (SDF-1) and its receptor C-X-C chemokine receptor-4 (CXCR4) are involved in human endometrial carcinoma (EC) progression. CXCR7 is another important receptor of SDF-1 and has a higher affinity with SDF-1 compared with that of CXCR4. This paper aims to study the effects of the SDF-1/CXCR7 axis on the growth and invasion ability of EC cells.
View Article and Find Full Text PDFTET1-GPER-PI3K/AKT pathway is involved in insulin-driven endometrial cancer cell proliferation.
Biochem Biophys Res Commun
January 2017
Large amount of clinical evidence has demonstrated that insulin resistance is closely related to oncogenesis of endometrial cancer (EC). Despite recent studies showed the up-regulatory role of insulin in G protein-coupled estrogen receptor (GPER/GPR30) expression, GPER expression was not decreased compared to control when insulin receptor was blocked even in insulin treatment. The purpose of this study was to explore the possible mechanism by which insulin up-regulates GPER that drives EC cell proliferation.
View Article and Find Full Text PDFObjective: This research was carried out to investigate the effectiveness, rationality, and safety of laparotomy management compared with uterine artery embolization (UAE) combined with methotrexate (MTX) for the treatment of deep implantation cesarean scar pregnancy (CSP II).
Materials And Methods: Data from 29 patients seen between June 2008 and February 2012 were retrospectively analyzed. The patients were divided into the surgery group and the UAE combined with MTX group according to the treatment they received.
The pathogenesis of preeclampsia is unclear but is thought to be related to shallow trophoblast invasion. An invasive phenotype is acquired by trophoblasts through the process of epithelial-mesenchymal transition (EMT). We proposed that EMT in trophoblasts is deregulated in preeclampsia.
View Article and Find Full Text PDFObjective: To investigate the relationship between the serum half life of CA(125) and the optimal operation rate and prognosis in patients with advanced epithelial ovarian carcinoma treated with neoadjuvant chemotherapy.
Methods: Clinical data of 39 patients who had undergone neoadjuvant chemotherapy were analyzed retrospectively. Patients were divided into two groups according to the serum half-life of CA(125), and the optimal operation rate and prognosis were compared.
[Study of differential gene expression in different stage human endometrial cancer].
Zhonghua Fu Chan Ke Za Zhi
January 2006
Article Synopsis
- - The study aimed to explore the gene expression profiles of different stages of endometrial cancer to find out which genes are linked to cancer progression and metastasis.
- - Researchers used cDNA microarray technology to analyze gene expression in 32 endometrial cancer samples, identifying 12 key genes that varied between cancer stages.
- - The findings showed a 66% agreement between the gene expression data and the clinical stages determined by the FIGO system, indicating that high-risk cancers could potentially be identified before surgery using this analysis method.
[Establishment of the model of heterotopic uterine transplantation in syngeneic rats].
Zhonghua Fu Chan Ke Za Zhi
May 2005
Objective: To develop a surgical method for establishment of a heterotopic uterine transplantation model in syngeneic rats and evaluate its feasibility.
Methods: Thirty pairs of Wistar rats aged 8 - 10 weeks were used as donor and recipient. Heterotopic uterine transplantation was conducted, and the duration of the operation was recorded.