Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer's Disease.

In this study, we aimed to work through the key genes involved in the process of pyroptosis in Alzheimer's disease (AD) to identify potential biomarkers using bioinformatics technology and further explore the underlying molecular mechanisms. The transcriptome data of brain tissue in AD patients were screened from the GEO database, and pyroptosis-related genes were analyzed. The functions of differential genes were analyzed by enrichment analysis and protein-protein interaction.

Applying meta-data of soybean grain in origin trace and quarantine inspection.

Soybean and derived products are among the most important food for both humans and animals. China is the world's largest importer of soybeans, with more than 100 million tons of annual imports, mainly from the United States of America (US), Brazil, and Argentina. However, there have been limited studies on the microbiota associated with imported soybean grains.

Oridonin Ameliorates Traumatic Brain Injury-Induced Neurological Damage by Improving Mitochondrial Function and Antioxidant Capacity and Suppressing Neuroinflammation through the Nrf2 Pathway.

Traumatic brain injury (TBI) is a global public health concern, and few effective treatments for its delayed damages are available. Oridonin (Ori) recently has been reported to show a promising neuroprotective efficacy, but its potential therapeutic effect on TBI has not been thoroughly elucidated. The TBI mouse models were established and treated with Ori or vehicle 30 min post-operation and every 24 h since then.

Transition metal atom doping of the basal plane of MoS monolayer nanosheets for electrochemical hydrogen evolution.

Surface sites of extensively exposed basal planes of MoS monolayer nanosheets, prepared BuLi exfoliation of MoS, have been doped with transition metal atoms for the first time to produce 2D monolayer catalysts used for the electrochemical hydrogen evolution reaction (HER). Their HER activity is significantly higher than the corresponding thin and bulk MoS layers. HAADF-STEM images show direct proof that single transition metal atoms reside at the surface basal sites, which subtly modify the electro-catalytic activity of the monolayer MoS, dependent on their electronic and stereospecific properties.

Modeling of lung's electrical impedance using fractional calculus for analysis of heat generation during RF-ablation.

Recently, Radio Frequency Ablation (RFA) is becoming a popular therapy for various cancers such as liver, breast, or lung cancer. RFA is one kinds of thermal therapy. However, it has been often reported about excessive ablation or non-ablation due to difficult control of ablation energy.

[Application of human oocyte morphometric parameters in assessment of fertilization and embryo development].

Objective: To investigate the correlation of human oocyte morphometric parameters with fertilization and embryo development in the intracytoplasmic sperm injection (ICSI) cycles.

Methods: The morphometric parameters of oocytes collected and submitted to evaluation using OCTAX Eye-ware software just before ICSI. Oocyte diameter (OD), perivitelline space width (PSW), zonapellucida thickness (ZPT) and the shape of first polar body (FPB) (intact or fragmented) were analyzed.

Real-time temperature control system based on the finite element method for liver radiofrequency ablation: effect of the time interval on control.

Radiofrequency (RF) ablation is increasingly being used to treat liver cancer because it is minimally invasive. However, it is difficult for operators to control the size of the coagulation zones precisely, because no method has been established to form an adequate and suitable ablation area. To overcome this limitation, we propose a new system that can control the coagulation zone size.

Validation of accuracy of liver model with temperature-dependent thermal conductivity by comparing the simulation and in vitro RF ablation experiment.

Radiofrequency (RF) ablation is increasingly used to treat cancer because it is minimally invasive. However, it is difficult for operators to control precisely the formation of coagulation zones because of the inadequacies of imaging modalities. To overcome this limitation, we previously proposed a model-based robotic ablation system that can create the required size and shape of coagulation zone based on the dimensions of the tumor.

Development of a temperature distribution simulator for lung RFA based on air dependence of thermal and electrical properties.

Radio frequency ablation (RFA) for lung cancer has increasingly been used over the past few years, because it is a minimally invasive treatment. As a feature of RFA for lung cancer, lung contains air. Air is low thermal and electrical conductivity.

On the structure of aspongopusin recently isolated from Aspongopus chinensis.

The 2,5-disubstituted oxazole recently proposed for aspongopusin, a natural product isolated from Aspongopus chinensis, was synthesized through an unambiguous route. The synthetic sample showed (1)H and (13)C NMR entirely different from those in the literature, revealing that the initially assigned structure was incorrect. The spectroscopic data for the given structure are thus made available for the first time.

[Protective effect of Xingnaojing and Xuesaitong injections on cerebral ischemic reperfusion injury in rats].

Objective: To investigate the mechanism of protective effect of Xingnaojing and Xuesaitong injections on cerebral ischemic reperfusion injury in rats.

Methods: The focal cerebral ischemia & reperfusion model was established by middle cerebral artery occlusion (MCAO). A total of 152 male SD rats were randomly assigned into 19 groups: sham operated group, Xingnaojing group, Xingnaojing plus Xuesaitong group and control group according to different reperfusion durations: 2, 4, 8, 24, 48, 72 h.

Resveratrol attenuates radiation damage in Caenorhabditis elegans by preventing oxidative stress.

Resveratrol, a member of a class of polyphenolic compounds known as flavonols, has been extensively studied for its anticancer, antiviral, anti-inflammatory, and neuroprotective roles. Caenorhabidits elegans is a well-established animal for investigating responses to radiation. We found that resveratrol may provide protection against hazardous radiation.

Diagnosis and treatment of organotin poisoned patients.

Background: With the development of industry and agriculture, organotin compounds have been widely used in China. Organotin compounds cause a common occupational poisoning. The toxicity of organotin was reported in animal studies; however the reports about human organotin intoxication are very rare.

Modulating the hybridization property of PNA with a peptoid-like side chain.

Modification on the gamma-N of the PNA backbone yielded a PNA analogue with a peptoid-like side chain. We found that the length of the side chain was important in influencing the hybridization affinity of the modified PNA.

Protein C-terminal modification through thioacid/azide amidation.

The preparation of protein bioconjugates has been largely dependent on the development of selective chemistries that are orthogonal to the diverse functionalities present in a protein. Here, we report a new method for C-terminus-directed modification of recombinant proteins. The method is based on the thioacid/azide amidation reaction.

BCSG1 methylation status and BCSG1 expression in breast tissues derived from Chinese women with breast cancer.

Objective: To investigate the role of DNA methylation in the regulation of BCSG1 gene expression in breast tissues derived from Chinese women with breast cancer.

Methods: The methylation status of exon 1 of the BCSG1 gene in breast cancer, and matched non-neoplastic adjacent and benign lesion tissues was extensively examined using methylation-specific PCR analysis. Corresponding mRNA expression levels were determined by real-time PCR.