Publications by authors named "Xiao-Shuang Xiang"
Article Synopsis
- Multiple system atrophy (MSA) is a challenging neurodegenerative disorder with symptoms like parkinsonism and cerebellar ataxia, which is poorly responsive to traditional treatments.
- A study examined the association of a specific genetic variant (SNP rs11931074) with MSA risk in a Chinese population, yet no significant differences were found in the genotypes between MSA patients and healthy controls.
- However, a meta-analysis suggested that the risk allele T of rs11931074 may increase the likelihood of developing MSA, highlighting possible genetic differences between Asian and Caucasian populations.
Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by α-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma α-synuclein levels in patients with multiple system atrophy. We studied plasma α-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls.
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