Application of the kurtosis statistic to the evaluation of the risk of hearing loss in workers exposed to high-level complex noise.

Objective: Develop dose-response relations for two groups of industrial workers exposed to Gaussian or non-Gaussian (complex) types of continuous noises and to investigate what role, if any, the kurtosis statistic can play in the evaluation of industrial noise-induced hearing loss (NIHL).

Design: Audiometric and noise exposure data were acquired on a population (N = 195) of screened workers from a textile manufacturing plant and a metal fabrication facility located in Henan province of China. Thirty-two of the subjects were exposed to non-Gaussian (non-G) noise and 163 were exposed to a Gaussian (G) continuous noise.

[Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring].

Objective: To evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension.

Methods: After 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95-114 mmHg and seated systolic blood pressure < 180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks.

Comparison of clinic and ambulatory blood pressure in response to antihypertensive drugs in Chinese patients.

Objective: To compare the difference between 24-h ambulatory blood pressure (ABP) and trough clinic blood pressure (CBP) after 8 weeks of therapy.

Methods: The study used meta-regression analysis to summarize three randomized, double-blind, active controlled trials in order to compare the difference between the magnitude of the reduction in 24-h average ABP and CBP Patients. Chinese patients with seated diastolic blood pressure (SDBP) 95-115 mmHg and ambulatory diastolic blood pressure (ADBP) > or =85 mmHg.

[Adaptive designs for clinical trial].

Objective: In order to provide readers with general concepts and methodology on adaptive designs for clinical trial.

Methods: Definition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example.

Results: The relationship between adaptive designs and group sequential design was summarized.

[Relationship between sample size and variation of means for personal noise exposure in weaving workers].

Objective: To explore the relationship between sample size and variance of means for personal noise exposure in weaving workers as to contributing evidence for establishing personal noise exposure measurement guideline.

Methods: A personal noise exposure measurement database from a group of weaving workers was used in the randomized re-sampling data analysis. The sampling cases were one number selecting from one to fifteen at each randomized re-sampling procedure.

[Adjustment of dose-response relationship of industrial impulse noise induced high frequency hearing loss with different exchange rate].

Objective: To explore a new method to evaluate the dose-response relationship between the noise exposure and prevalence of noise induced high frequency hearing loss.

Methods: Physical examination and questionnaire survey were conducted among 32 mechanical workers, 12 males and 20 females, aged 35.1 +/- 7.

[Relationship between impulse noise and continuous noise inducing hearing loss by dosimeter measurement in working populations].

Objective: To compare the dose-response relationship differences between impulse noise exposure workers and continuous noise exposure workers in prevalence of noise inducing hearing loss using dosimeter measurement.

Methods: Thirty-two mechanical workers in a workshop were selected as impulse noise group and 163 textile workers in a textile factory as continuous noise group. SH-126 dosimeter was used to measure A weighted equal sound level of eight hours (L(Aeq.