Efficacy of EGFR-TKI sequential therapy in patients with exon 19 insertion-positive non-small-cell lung cancer: A case report.

Background: Insertions in exon 19 in the epidermal growth factor receptor gene (EGFR) is a rarely seen mutation in non-small cell lung cancer. These patients have been effectively treated with sequential EGFR tyrosine kinase inhibitors (TKIs).

Case Summary: Here, we presented a case of non-small cell lung cancer, stage IIIB, with exon 19 insertion mutation as detected in the right lower lobe by next-generation sequencing.

[The prevalence and risk factors of occupational asthma in workers exposed to isocyanate].

Objective: To investigate the prevalence of occupational asthma, airway inflammation and analyze the risk factors for workers exposed to isocyanates.

Methods: A cross-sectional study was applied. Totally 429 isocyanates exposed workers were surveyed and the prevalence of occupational asthma and airway inflammation situation were examined by questionnaire, physical examination and laboratory tests.