Publications by authors named "Xiao-Qian Shi"

Objective: Resveratrol (Res) is a promising anticancer drug against hepatocellular carcinoma (HCC), but whether its anti-HCC effects implicate mitophagy remains unclear. Therefore, we aimed to explore the specific role of Res in mitophagy and the related mechanisms during the treatment of HCC.

Methods: HepG2 cells and tumor-grafted nude mice were used to investigate the effects of low-, middle- and high-dose of Res on HCC progression and mitophagy in vitro and in vivo, respectively.

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  • "Zaojiaomi" is a traditional food derived from the endosperm of specific plant species, but there's limited study on Gymnocladus chinensis endosperm.
  • A research study used a metabolomics approach to analyze and compare the metabolites in Gymnocladus chinensis, Gleditsia sinensis, and Gleditsia japonica endosperms, identifying a significant number of different metabolites.
  • The findings suggest that Gymnocladus chinensis has unique compounds that could enhance antioxidant activity and is rich in beneficial nutrients like L-arginine and zinc, highlighting its potential as a functional food.
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, commonly known as Chinese Zaojiao, has important economic value and medicinal compounds in its fruits and thorns, making it widely cultivated artificially in China. However, the available literature on the impact of waterlogging on the growth of seedlings and the accumulation of metabolite compounds in its thorns is limited. To address this knowledge gap, seedlings were planted in soil supplemented with pindstrup substrate, which enhances the water-holding capacity of the soil.

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rs2736098 is a synonymous polymorphism in TERT (telomerase reverse transcriptase), an enzyme involved in tumor onset of multiple tissues, and should play no roles in carcinogenesis. However, a search in cancer somatic mutation database indicated that the mutation frequency at rs2736098 is much higher than the average one for . Moreover, there are significant H3K4me1 and H3K27Ac signals, two universal histone modifications for active enhancers, surrounding rs2736098.

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Alpine Rhododendron species are prominent constituents and renowned ornamental plants in alpine ecosystems. Consequently, evaluating the genetic variation in embolism resistance within the genus Rhododendron and predicting their adaptability to future climate change is important. Nevertheless, the assessment of embolism resistance in Rhododendron species remains limited.

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  • * Scientists studied genetic variations and discovered that one of the rare genetic patterns came from Neanderthals, and certain genetic changes can affect how our bodies work.
  • * The research suggests that Neanderthals may have had lower levels of a specific protein that helps manage energy in the body, which could explain some differences between Neanderthals and modern humans.
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In recent years, petal blight disease caused by pathogens has become increasingly epidemic in . Breeding disease-resistant rhododendron is considered to be a more environmentally friendly strategy than is the use of chemical reagents. In this study, we aimed to investigate the response mechanisms of rhododendron varieties to petal blight, using transcriptomics and metabolomics analyses.

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Asthma is a complex disease, often with evident genetic predisposition; for example, the single-nucleotide polymorphism (SNP) rs7130588 was significantly associated with asthma by genome-wide association study (GWAS). Analysis of 1000 Genomes Project data suggests that there is another SNP, rs6592645, in complete linkage disequilibrium with rs7130588 and should present the same signal in GWAS. However, the causal SNP and the mechanism for the association between rs7130588 and asthma remain to be elucidated.

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Introduction: Small cell lung cancer (SCLC) is featured by a high TP53 mutant rate. Our previous research found that arsenic trioxide (AsO) could significantly inhibit the growth and metastasis of SCLC. Studies have shown that the degradation of mutant p53 mediated by murine double minute 2 (MDM2) can be induced by AsO, which probably contributes to the inhibition of SCLC, but the detailed mechanism is still unclear.

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  • Lung cancer is a hereditary malignant tumor with high mortality rates, and certain genetic variations (SNPs) are linked to increased risk.
  • Initial studies identified the SNP rs748404 at the TGM5 gene promoter, and further analysis found five additional SNPs associated with lung cancer risk.
  • Functional assays revealed that the actual causal SNPs are rs66651343 and rs12909095, which interact with the CCNDBP1 promoter and influence its expression through transcription factor binding.
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Drug-resistant advanced lung adenocarcinoma (LUAD) is an aggressive malignancy with limited treatment options. A therapeutic strategy for drug-resistant LUAD is to target the tumor associated macrophages (TAMs), because they play an important role in tumor immune escape, progression and metastasis. In this study, we conducted in vivo and in vitro investigation of the inhibitory effect of arsenic trioxide (ATO) on polarization of TAMs educated by LUAD.

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Our previous work identified one region upstream human UGT2B4 (UDP glucuronosyltransferase family 2 member B4) which is associated with breast cancer and under balancing selection. However, the distribution, functional variation and molecular mechanism underlying breast cancer and balancing selection remain unclear. In current study, the two haplotypes with deep divergence are described by analyzing 1000 genomes project data and observed to be with high frequencies in all human populations.

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Breast cancer is the cancer type with the highest morbidity rates in women, and previous genome-wide association studies (GWASs) have suggested that the single nucleotide polymorphism (SNP) rs1011970 is significantly associated with this disease. An analysis of data from the 1000 Genomes Project demonstrated that there is an SNP, rs77283072, in almost complete linkage disequilibrium with rs1011970, which should therefore present the same signal in a GWAS. However, the actual causal SNP and its associated underlying mechanism have yet to be elucidated.

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  • Lung cancer is linked to certain genes, and researchers studied a specific gene variation (rs2853677) that seemed to be related to lung cancer risk, but found it doesn't actually change gene expression.
  • They discovered another variation (rs2736099) next to it that does affect how genes work and is likely responsible for the lung cancer connection.
  • The study shows how understanding these genetic changes can help us learn more about why lung cancer happens and might help with understanding other types of cancer too.
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Background: Anti-angiogenesis therapy mostly aimed at targeting vascular endothelial growth factor (VEGF) and its receptors have been widely applied to lung cancer. However, the improvement in the patient's overall survival remains dissatisfying. Previously, we demonstrated that arsenic trioxide (AsO) exerts an anti-lung cancer effect through anti-angiogenesis, but the details of the mechanism in play remain unclear.

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Due to its vulnerability and anthropogenic disturbance, ecological problems in karst areas are prominent, such as vegetation destruction, soil erosion, and rocky desertification. Comprehensive analysis of ecological vulnerability and influencing factors in karst areas can provide scientific support for regional ecological restoration and environmental governance. With Guangnan County, a typical karst region in southeastern Yunnan, as an example, we constructed a karst regional eco-environmental vulnerability assessment index system from the perspective of natural and factitious factors.

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A novel and convenient strategy for the enantioselective synthesis of γ-lactam derivatives via N-heterocyclic carbene catalyzed formal [3 + 2] annulation of enals with 2-aminoacrylates is disclosed. This activation mode provides a complementary approach to the synthesis of various γ-lactam derivatives in good yields with excellent diastereo- and enantioselectivities. In this process, two consecutive stereocenters are constructed, and a quaternary carbon center is also established.

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A strategy for the NHC-catalyzed synthesis of dihydropyridinones and spirooxindoles has been developed via [3+3] annulation reactions of enals or isatin-derived enals with 2-aminoacrylates under oxidative conditions. In this efficient strategy, the 2-aminoacrylates served as nucleophiles. Modifying the standard base switched the carbon-carbon double bond formation from 5,6-positions to 3,4-positions to generate 5,6-dihydropyridinones and 3,4-dihydropyridinones, respectively.

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Objective: To study the death burden of chronic obstructive pulmonary diseases (COPD) in west rural areas of China in 2004 - 2005.

Methods: The data from 2004 - 2005 the Third National Mortality Retrospective Sampling Survey were used in the study. A total of 28 621 276 person years were investigated in west rural areas, which covered 12 provinces, and consisted of 42 surveillance districts.

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