Publications by authors named "Xiao-Qian Jiao"
Article Synopsis
- Nucleoside analogs are the main antiviral drugs used for treating feline herpesvirus-1 (FHV-1), but they face issues like drug resistance and a limited mechanism of action.
- This research highlights the need for new antiviral drugs and investigates natural compounds that can effectively target the virus's glycoprotein B (gB) using techniques like Bio-layer interferometry (BLI).
- The study found that compounds Saikosaponin B2, Punicalin, and Punicalagin demonstrated strong antiviral effects against FHV-1 without being toxic to cells, particularly by preventing the virus from entering cells in the early stages of infection.
