Adduct of Pesticide and Lignocellulosic Waste via Cleavable Silaketal Linkages for Agricultural Double Reduction.

The abuse of hazardous agrochemicals leads to excessive toxic agricultural emissions, posing a tremendous threat to the natural surroundings and human well-being. In practice, the amount of pesticides in protecting crops is often far less than that lost into the environment through evaporation and leaching. Minimizing the use of pesticides as well as improving their use efficiency has been included in the policy of "agricultural double reduction," besides replacing the chemical fertilizer with straw returning.

Deepened Photodynamic Therapy through Skin Optical Clearing Technology in the Visible Light Window.

The trade-off that shorter wavelength light facilitates the efficient generation of reactive oxygen species (ROS) from photosensitizer (PS) while facing the drawback of limited penetration depth through skin tissue restricts the further development of photodynamic therapy (PDT). Here, we address this contradiction and achieve visible-light-tailored deep PDT combined with the skin optical clearing technology. With the help of the prepared skin optical clearing gel, the refractive index inhomogeneity between skin tissue components is greatly attenuated, and the light scattering effect within the skin tissue is remarkably reduced.

Ultradeep Photothermal Therapy Strategies.

Photothermal therapy (PTT) mediated by the second near-infrared light (NIR-II) is considered as the most promising PTT in deep tissues due to the superior penetrability of NIR-II through biological tissues. However, the effective therapeutic depth of NIR-II mediated PTT is limited to only several millimeters beneath the skin tissues. So far, deep PTT still cannot satisfy the depth requirement for most common cancers, including but not limited to lung, pancreatic, colorectal, and stomach cancers.

Controllable Degradation of Polyurethane Thermosets with Silaketal Linkages in Response to Weak Acid.

Polyurethane (PU) thermosets offer great favors to our daily life on account of their excellent mechanical, physical, and chemical properties as well as appreciable biocompatibility. Nevertheless, PU waste is increasingly causing environmental and health-related problems as it is mostly resistant to chemical degradation under mild conditions. Herein, we report a kind of PU thermoset with silaketal leakages in its main chains to enable polymer degradation in response to weak acids, even in edible vinegar.

Superhydrophilic 2D Covalent Organic Frameworks as Broadband Absorbers for Efficient Solar Steam Generation.

The intrinsic hydrophobicity and limited light absorption especially in the near-infrared (NIR) region of porous organic polymers are two bottlenecks impeding their applications in solar steam generation (SSG). Herein, we develop a 1,4,5,8-tetrakis(phenylamino)anthracene-9,10-dione (TPAD)-based covalent organic framework (COF) (TPAD-COF) featuring both superhydrophilicity and broad light absorption covering from the entire UV/Vis to NIR regions for SSG. TPAD-COF serving as a highly efficient photothermal conversion material without any additives displays an excellent water evaporation of 1.

Coupling molecular rigidity and flexibility on fused backbones for NIR-II photothermal conversion.

Great attention is being increasingly paid to photothermal conversion in the near-infrared (NIR)-II window (1000-1350 nm), where deeper tissue penetration is favored. To date, only a limited number of organic photothermal polymers and relevant theory have been exploited to direct the molecular design of polymers with highly efficient photothermal conversion, specifically in the NIR-II window. This work proposes a fused backbone structure locked an intramolecular hydrogen bonding interaction and double bond, which favors molecular planarity and rigidity in the ground state and molecular flexibility in the excited state.

[Study on physicochemical properties of paeonol-Helix aspersa muller nanogel and its inhibitory effects on hypertrophic scar tissue in rabbit ear].

To prepare Helix aspersa muller-paeonol nanogel( PAE-HAM-Gels) with anti-proliferative scar effect,evaluate its skin penetration,retention and irritation,and to investigate its prevention and treatment effect for hypertrophic scar in rabbit ears. The dermal retention,transdermal rate and cumulative permeability of paeonol were investigated in vitro by using the modified Franz diffusion cell and the abdominal skin of suckling pigs,SD rats and KM mice,respectively,and the in vitro permeation curves were drawn. The normal skin of the back of New Zealand rabbits was continuously treated with PAE-HAM-Gels for 7 days,and the physiological state of the skin was observed under light microscope after HE staining by using homologous left and right contrast method.

[Effect of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B on proliferation,migration and cell cycle of human skin fibroblasts].

Hypertrophic scar( HS) is a very common skin fibrosis disorder after human skin injury and wound healing. The objective of this study was to investigate the efficacy of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B( SAB-TAT-LIP) on proliferation,migration and cell cycle of human skin fibroblasts( HSF),and preliminarily evaluate its effect on prevention and treatment of HS. HSF were cultured in vitro,and MTT assay was used to detect the inhibitory effect of SAB-TAT-LIP on cell proliferation.

Polydiacetylene-Polyurethane Crisscross Elastomer as an Intrinsic Shape Memory Conductive Polymer.

Owing to the high phase transition temperature and incompatibility with thermoplastic elastomers, conjugated polymers are hardly formulated as shape memory materials. This work presents a crisscross polymer composed of polyurethane and polydiacetylene. Phase separation is completely avoided based on the photoinduced polymerization of polydiacetylene from polyurethane chains.

Crystal-confined freestanding ionic liquids for reconfigurable and repairable electronics.

Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowing ionic liquid [OMIm]PF is confined by another azobenzene-containing ionic liquid crystalline [OMIm]AzoO.

Spider-Inspired Multicomponent 3D Printing Technique for Next-Generation Complex Biofabrication.

The shortage of tissue resources is currently a serious challenge that limits the clinical therapy to patients with tissue loss or end-stage organ failure. The booming development of 3D printing offers unprecedented hope for tissue engineering since it can construct cells and biomaterials into a 3D tissue-mimicking object with precise control over size and shape. However, it is still challenging to fabricate artificial living tissues or organs due to the extreme complexity of biological tissues.

Dark Ionic Liquid for Flexible Optoelectronics.

Owing to a wide visual angle, few aberrations, and great depth of focus, flexible optoelectronics have become one subject of intense investigation for rescue equipment and endoscopy tools. Ionic liquids are rising as a kind of fluidic "semiconductor" with advantages of high flexibility and self-healing. However, challenges in the molecular design of photoresponsive ionic liquids impede the exploration of ionic liquids as intrinsic flexible liquid optoelectronics.

A Degradable and Recyclable Photothermal Conversion Polymer.

Decomposition and repolymerization of conjugated polymers offer great promise for developing recyclable photothermal conversion materials, which yet remain challenging. Herein, a crosslinked conjugated polymer based on a dynamic covalent bond of Schiff base is developed. This polymer possesses photothermal conversion efficiency as high as 90.

Formulating Polyethylene Glycol as Supramolecular Emulsifiers for One-Step Double Emulsions.

One-step double emulsions via only one-step emulsification are leading to an attractive branch of emulsion research studies owing to the ease of preparation and reduced surfactant numbers. In addition to controlling the oil/water ratio, exploiting emulsifiers with desirable amphiphilicity that can stabilize both the inner and outer water/oil interfaces is crucial to the formation of one-step double emulsions. In particular, new emulsifiers with saving laborious efforts are highly preferred in consideration of low cost and practical applications.

N(2)-Selective Iodofunctionalization of Olefins with NH-1,2,3-Triazoles to provide N(2)-Alkyl-Substituted 1,2,3-Triazoles.

A new method was developed to synthesize N(2)-alkyl-substituted 1,2,3-triazole through N-iodosuccinimide (NIS) mediated iodofuctionalization reaction of the alkene group with bi-, mono-, and unsubstituted NH-1,2,3-triazoles. The favored N-1 type hydrogen bond between the iodonium ion intermediate and 1,2,3-triazole was supposed to be generated, which gave the desired N(2)-alkyl triazole with a high N(2)-selectivity.

Radiofrequency Thermocoagulation in Relieving Refractory Pain of Knee Osteoarthritis.

To investigate the efficacy of radiofrequency thermocoagulation (RFTC) in relieving refractory pain of knee osteoarthritis (OA), we selected 54 patients with chronic knee OA pain, 27 treated with RFTC (case group) and 27 receiving regular treatments (control group). Response evaluations were conducted before treatment, and at the termination of treatment, and 3-month follow-up, applying the visual analog scale, the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and American Knee Society Score (AKSS). Data analyses were performed with SPSS 21.