Publications by authors named "Xiao-Ping Liu"

Article Synopsis
  • The study reports the observation of bulk quantum Hall effect (QHE) in large TaP crystals, which is a significant advancement compared to previous findings in smaller 2D systems.
  • This phenomenon is characterized by simultaneous quantum plateaus in both transverse and vertical resistivity, indicating coherent electron transport.
  • The observed bulk QHE occurs due to the interaction of Landau cyclotron movement in a magnetic field and the periodic structure of nanometer-scale lamellae, suggesting that engineering microstructures can enhance electron transport in bulk materials.
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The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers. In an animal feeding experiment, 288 male yellow-feather broilers (1 day old) were randomly allocated to four treatment groups with six replicates of 12 birds each. The control (CON) group was fed a basal diet.

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Article Synopsis
  • Ganoderma lucidum polysaccharides (GLP) have antioxidant and immune-boosting properties, and HWE-JGLR, derived from its hot water extract, is rich in these compounds.
  • This study evaluated the effects of HWE-JGLR supplementation on the growth, serum biochemistry, antioxidant abilities, and gut bacteria of yellow-feathered broilers, comparing it to a standard corn-soybean meal diet.
  • Results revealed that HWE-JGLR improved good cholesterol levels, reduced triglycerides, enhanced antioxidant functions through specific signaling pathways, and altered gut microbiota composition, highlighting its potential as a valuable green feed additive.
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Objective: This study aimed to analyze the effect of low-molecular-weight heparin (LMWH) on the decidualization of stromal cells in early pregnancy and explore the effect of LMWH on pregnancy outcomes.

Methods: Recurrent spontaneous abortion (RSA) mouse model (CBA/J × DBA/2) and normal pregnant mouse model (CBA/J × BALB/c) were established. The female mice were checked for a mucus plug twice daily to identify a potential pregnancy.

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In insects, vitellogenin (Vg) is generally viewed as a female-specific protein. Its primary function is to supply nutrition to developing embryos. Here, we reported Vg from the male adults of a natural predator, Chrysopa pallens.

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Recently, the discovery of optical spatiotemporal (ST) vortex beams with transverse orbital angular momentum (OAM) has attracted increasing attention and is expected to extend the research scope and open new opportunities for practical applications of OAM states. The ST vortex beams are also applicable to other physical fields that involve wave phenomena, and here we develop the ST vortex concept in the field of acoustics and report the generation of Bessel-type ST acoustic vortex beams. The ST vortex beams are fully characterized using the scalar approach for the pressure field and the vector approach for the velocity field.

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Objective: To explore the lactate-related genes (LRGs) in lung adenocarcinoma (LUAD) by various methods, construct a prognostic model, and explore the relationship between lactate subtypes and the immune tumor microenvironment (TME).

Methods: 24 LRGs were collected. The mutation landscape and the prognosis value of LRGs were explored by using The Cancer Genome Atlas (TCGA) data.

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Background: Mounting evidence has demonstrated that an imbalance in liquid-liquid phase separation (LLPS) can induce alteration in the spatiotemporal coordination of biomolecular condensates, which plays a role in carcinogenesis and cachexia. However, the role of LLPS in the occurrence and progression of bladder cancer (BLCA) remains to be elucidated. Identifying the role of LLPS in carcinogenesis may aid in cancer therapeutics.

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In order to take advantage of both immunotherapeutic and metabolic antitumor agents, novel dual indoleamine 2,3- dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) inhibitors were designed. Thioredoxin reductase 1 (TrxR1) is a main ROS modulator within CRC cells. Indoleamine 2,3-dioxygenase (IDO1) is crucial controller for tryptophan (Trp) metabolism that is also important for CRC immunotherapy.

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The variegated leaves and fragrant flowers of Daphne odora var. marginata Mak. make it a popular garden plant.

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Postinfectious irritable bowel syndrome (PI-IBS) is a highly prevalent gastrointestinal disorder associated with immune dysregulation and depression- and anxiety-like behaviors. Through traditional medicine, the active ingredient of Paeoniae Radix called paeoniflorin (PF) was previously found to prevent the symptoms of PI-IBS. However, there is limited information on the effects of PF on intestinal function and depression- and anxiety-like symptoms in PI-IBS animal models.

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Coronavirus Disease 2019 (COVID-19) is currently a global pandemic, and early screening is one of the key factors for COVID-19 control and treatment. Here, we developed and validated chest CT-based imaging biomarkers for COVID-19 patient screening from two independent hospitals with 419 patients. We identified the vasculature-like signals from CT images and found that, compared to healthy and community acquired pneumonia (CAP) patients, COVID-19 patients display a significantly higher abundance of these signals.

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Objective: To investigate the expression of ROBO3 in pediatric AML patients and explore its function on cell proliferation and apoptosis.

Methods: The expression of ROBO3 in pediatric AML patients at different treatment stage was detected by real-time quantitative polymerase chain reaction (RT-qPCR). The relationship between the expression of ROBO3 and clinic pathological characteristics in newly diagnosed pediatric AML patients was analyzed.

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Article Synopsis
  • Atherosclerosis is a primary cause of coronary artery ostial lesions, but secondary lesions, which are rare, can be easily overlooked and lead to misdiagnosis.
  • This report details three patients who experienced acute myocardial infarction and unstable angina due to secondary coronary artery ostial lesions that stemmed from various causes, including tumors and anatomical anomalies.
  • The findings highlight the importance of considering alternate causes beyond atherosclerosis when diagnosing coronary ostial lesions.
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  • NAPSB was found to be downregulated in hepatocellular carcinoma (HCC) patients, with higher levels indicating better survival outcomes and immune activation.
  • The study employed various methods, including public dataset analysis and biological enrichment techniques, to assess NAPSB's role in HCC and its relationships with T cell activity and tumor microenvironment.
  • Findings suggest that NAPSB could serve as a predictive marker for prognosis and response to immunotherapy and chemotherapy in HCC, linked to mechanisms of cancer cell death.
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Objective: Gliomas are the most common tumors in the central nervous system. The cancer susceptibility candidate 15 (CASC15) gene has been reported to be a susceptibility gene for several types of cancer. No studies have been carried out on the predisposing effect of CASC15 gene single nucleotide polymorphisms (SNPs) on glioma risk.

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Background: Lower-grade gliomas (LGG) are heterogeneous diseases by clinical, histological, and molecular criteria. We aimed to personalize the diagnosis and therapy of LGG patients by developing and validating robust cellular morphometric subtypes (CMS) and to uncover the molecular signatures underlying these subtypes.

Methods: Cellular morphometric biomarkers (CMBs) were identified with artificial intelligence technique from TCGA-LGG cohort.

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  • COVID-19 emerged in late 2019 and affects children differently than adults, with lower severity and death rates; Kawasaki disease (KD) cases have surged in various regions during the pandemic.
  • A total of 24 COVID-19 cases and 268 KD cases were analyzed, revealing significant differences in lab results and clinical characteristics between the two conditions in children.
  • Key markers like high white blood cell counts, platelets, and procalcitonin can help distinguish between COVID-19 and KD, indicating that clinicians should monitor these levels to ensure early diagnosis of related conditions.
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Studies of the encoding of sensory stimuli by the brain often consider recorded neurons as a pool of identical units. Here, we report divergence in stimulus-encoding properties between subpopulations of cortical neurons that are classified based on spike timing and waveform features. Neurons in auditory cortex of the awake marmoset (Callithrix jacchus) encode temporal information with either stimulus-synchronized or nonsynchronized responses.

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  • Researchers used computer programs to study tiny details in cancer cells from mouse tumors.
  • They found two types of cancer cell shapes, and one type (CMS-2) was linked to shorter survival rates for mice and people with breast cancer.
  • This new way of looking at cancer could help doctors understand patient care better using regular cancer test images.
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Background: Viral resistance to existing inhibitors and the time-dependent effectiveness of neuraminidase inhibitors have limited the number of antivirals that can be used for prophylaxis and therapeutic treatment of severe influenza infection. Thus, there is an urgent need to develop new drugs to prevent and treat influenza infection.

Objective: The aims of this study was to design and synthesize a novel series of 2-ureidonicotinamide derivatives and evaluate their anti-IAV activities.

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Background: Epidemiological studies have found that the prevalence of chronic heart failure in China is 0.9%, the number of people affected is more than 4 million, and the 5-year survival rate is even lower than that of malignant tumors.

Aim: To determine the impact of WeChat platform-based health management on severe chronic heart failure patients' health and self-management efficacy.

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Studies have shown that the change in lumbar spine bone mineral density with different osteoporosis drugs had a beneficial effect on the frequency of new vertebral and nonvertebral fractures in postmenopausal females, but their results were conflicting. This meta-analysis was performed to evaluate this relationship. A systematic literature search up to May 2020 was performed and 20 studies with 73,390 postmenopausal females were included; of them, a total of 41,980 were treated with osteoporosis drugs and 31,410 with placebo.

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Article Synopsis
  • Weyl semimetals exhibit unique electronic features like Weyl points and Berry curvature, leading to interesting properties that have been experimentally confirmed.
  • The study focuses on high-order harmonic generation (HHG) in type-II Weyl semimetal β-WP crystals, successfully producing odd and even orders with spectra extending into the vacuum ultraviolet region.
  • The research reveals that odd harmonics arise from Bloch electron oscillations, while even harmonics are influenced by the Berry curvature, paving the way for new applications in deep ultraviolet radiation and characterizing complex electronic structures in quantum materials.
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Objective: This study aimed to establish a model to distinguish Kawasaki disease (KD) from other fever illness using the prognostic nutritional index (PNI) and immunological factors.

Method: We enrolled a total of 692 patients (including 198 with KD and 494 children with febrile diseases). Of those, 415 patients were selected to be the training group and 277 patients to be the validation group.

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