Changes in peripheral T-lymphocyte subsets and serum cytokines in patients with systemic sclerosis.

T cells represent a predominant cell type in autoimmune disease. However, their exact roles are not fully clear in systemic sclerosis (SSc). This study aimed to mainly investigate the alteration in the absolute numbers of T-lymphocyte subsets and the serum levels of cytokines in SSc patients.

Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe?

, a transmembrane mucin, plays important roles in epithelial renewal and differentiation. Recent studies suggest that has been implicated in pancreatic cancer pathogenesis and is expressed in various normal and cancer tissues. The underlying features of across various cancer types may allow us to ensure appropriate treatment and patient monitoring.

A rare case of inflammation after total hip arthroplasty due to a malpositioned prosthesis: A case report.

Rationale: Although prosthetic loosening caused by poor prosthesis positioning is common after total hip arthroplasty (THA), an inflammation caused by poor prosthesis positioning is rare. We report a case in which a THA-related inflammation was indeed caused by poor prosthesis positioning.

Patient Concerns: A 64-year-old woman was admitted to our hospital with a history of persistent hip pain that had started after she had undergone THA 4 years previously.

[Research progress on the monitoring methods of atmospheric nitrogen deposition].

As an important component of global nitrogen (N) biogeochemical cycle, atmospheric N deposition refers to the removal process of reactive N, including oxidized N (NO) and reduced N (NH), from the atmosphere to earth surface through dry and wet deposition. Nitrogen deposition can exert important impacts on the structure and functioning of both terrestrial and aquatic ecosystems. Increasing N deposition poses a potential threat to natural ecosystems and human health.

microRNA-542-5p protects against acute lung injury in mice with severe acute pancreatitis by suppressing the mitogen-activated protein kinase signaling pathway through the negative regulation of P21-activated kinase 1.

Severe acute pancreatitis (SAP) is a condition associated with high rates of mortality and lengthy hospital stays. In the current study, SAP mouse models were established in BALB/c wild-type and P21-activated kinase 1 (PAK1) knockdown mice with the objective of determining the expression of microRNA-542-5p (miR-542-5p) and the subsequent elucidation of the mechanism by which it influences acute lung injury (ALI) by mediating mitogen-activated protein kinase (MAPK) signaling and binding to PAK1. The targeting relationship between miR-542-5p and PAK1 was verified using the bioinformatics prediction website and by the means of a dual-luciferase reporter assay.

MicroRNA-339-3p alleviates inflammation and edema and suppresses pulmonary microvascular endothelial cell apoptosis in mice with severe acute pancreatitis-associated acute lung injury by regulating Anxa3 via the Akt/mTOR signaling pathway.

Severe acute pancreatitis (SAP) is a disease with a high mortality. Patients with SAP may also be complicated with acute lung injury (ALI). So far the therapy for SAP-ALI is still limited.

Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling.

Objectives: Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an study.

[Effects of enhanced-efficiency nitrogen fertilizers on nitrous oxide emissions from cotton field under plastic mulched drip irrigation in Xinjiang,China].

The effect of enhanced-efficiency nitrogen (N) fertilizers on emissions of nitrous oxide (NO) from the grey desert agricultural soils of Xinjiang is uncertain. In this study, the enhanced-efficiency fertilizers, polymer-coated urea (ESN), and stabilized urea with urease and nitrification inhibitors (U+I) were compared to conventional urea (U) for NO emissions from cotton under plastic mulch drip irrigation near Urumqi, Xinjiang. ESN was added once at planting but the other treatments were added multiple times with drip irrigation during the growing season.