Publications by authors named "Xiao-Pei Lu"

Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder with four causative genes (SLC20A2, PDGFRB, PDGFB, and XPR1) that have been identified. Here, we aim to describe the mutational spectrum of four causative genes in a series of 226 unrelated Chinese PFBC patients. Mutations in four causative genes were detected in 16.

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Article Synopsis
  • A new assay using protein precipitation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been created and tested for measuring Sodium Tanshinone IIA Sulfonate (STS) in human plasma.
  • The process involves adding an internal standard (DHEAS-D5) and using a specific mixture of acetonitrile and methanol for sample preparation, followed by detection through a specialized mass spectrometer.
  • The method shows high accuracy and precision, with a calibration range of 2-1000 ng/mL and has been successfully used in a pharmacokinetic study with male volunteers in China.*
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