Publications by authors named "Xiao-Nan Zhong"
Article Synopsis
- Th9 cells, a subtype of CD4+ T helper cells known for high IL-9 secretion, are implicated in the pathology of multiple sclerosis (MS) and interact with mast cells, which are crucial in immune responses.
- This study investigated the effects of neutralizing IL-9 through antibody treatment in a mouse model of MS (experimental autoimmune encephalomyelitis - EAE), analyzing clinical scores and mast cell activity in the central nervous system (CNS).
- Results showed that blocking IL-9 delayed the onset of EAE and reduced disease severity, correlating with decreased mast cell infiltration in the CNS.
Background: High levels of nitric oxide (NO) produced by inducible NO synthase (iNOS) have been associated with atherosclerosis processes. Naoxintong is a traditional Chinese medicine for treatment of cerebrovascular and cardiovascular disease. The aim of the present study was to detect and quantify changes of iNOS mRNA and NO levels in the vessel wall after the administration of Naoxintong in an atherosclerotic rabbit model.
View Article and Find Full Text PDFBackground: Despite the large scale technical innovations that have been made, a number of patients with neuromyelitis optica (NMO) are lacking NMO-IgG in both serum and cerebrospinal fluid. Longitudinally extensive spinal cord (LESC) lesions and linear lesions are associated with NMO. However, differences of spinal cord magnetic resonance imaging (MRI) features, including LESC lesions and linear lesions, between NMO-IgG positive and negative patients still remain unknown.
View Article and Find Full Text PDF