A feasibility study of DNA ploidy analysis, HPV, and TCT for screening of cervical cancer: A retrospective study.

The present study aimed to evaluate the application of DNA ploidy analysis, human papillomavirus (HPV-DNA) test, and thin-prep cytologic test (TCT) for mass screening of cervical cancer (CC). A total of 13,830 patients who underwent both TCT and HPV-DNA tests from June 2021 to June 2022 were selected as study participants (10,107 patients from Shandong Provincial Hospital, 2447 patients from First People's Hospital of Tancheng County, and 1276 patients from Liaocheng People's Hospital). We also conducted a DNA ploidy analysis and compared the results.

Identification and validation of biomarkers related to mitochondria during ex vivo lung perfusion for lung transplants based on machine learning algorithm.

Background: Ex vivo lung perfusion (EVLP) is a critical strategy to rehabilitate marginal donor lungs, thereby increasing lung transplantation (LTx) rates. Ischemia-reperfusion (I/R) injury inevitably occurs during LTx. Exploring the common mechanisms between EVLP and I/R may unveil new treatment targets to enhance LTx outcomes.

Fabrication of Ultrahigh-Loading Dual Copper Sites in Nitrogen-Doped Porous Carbons Boosting Electroreduction of CO to CH Under Neutral Conditions.

Synthesis of high-loading atomic-level dispersed catalysts for highly efficient electrochemical CO reduction reaction (eCORR) to ethylene (CH) in neutral electrolyte remain challenging tasks. To address common aggregation issues, a host-guest strategy is employed, by using a metal-azolate framework (MAF-4) with nanocages as the host and a dinuclear Cu(I) complex as the guest, to form precursors for pyrolysis into a series of nitrogen-doped porous carbons (NPCs) with varying loadings of dual copper sites, namely NPC-Cu-21 (21.2 wt%), NPC-Cu-11 (10.

Continuous Electrosynthesis of Pure HO Solution with Medical-Grade Concentration by a Conductive Ni-Phthalocyanine-Based Covalent Organic Framework.

Electrosynthesis of HO provides an environmentally friendly alternative to the traditional anthraquinone method employed in industry, but suffers from impurities and restricted yield rate and concentration of HO. Herein, we demonstrated a Ni-phthalocyanine-based covalent-organic framework (COF, denoted as ) with a higher inherent conductivity of 1.14 × 10 S m, which exhibited an ultrahigh current density of 530 mA cm with a Faradaic efficiency (HO) of ∼100% at a low cell voltage of 3.

Research on time-division multiplexing for error correction and privacy amplification in post-processing of quantum key distribution.

The post-processing of quantum key distribution mainly includes error correction and privacy amplification. The error correction algorithms and privacy amplification methods used in the existing quantum key distribution are completely unrelated. Based on the principle of correspondence between error-correcting codes and hash function families, we proposed the idea of time-division multiplexing for error correction and privacy amplification for the first time.

Long-Term Stable and Multifeature Microfluidic Impedance Flow Cytometry Based on a Constricted Channel for Single-Cell Mechanical Phenotyping.

The microfluidic impedance flow cytometer (m-IFC) using constricted microchannels is an appealing choice for the high-throughput measurement of single-cell mechanical properties. However, channels smaller than the cells are susceptible to irreversible blockage, extremely affecting the stability of the system and the throughput. Meanwhile, the common practice of extracting a single quantitative index, i.

Percutaneous endobiliary radiofrequency ablation and stent placement for unresectable malignant biliary obstruction: a propensity score matching retrospective study.

Background: Whether endobiliary radiofrequency ablation (EB-RFA) changes the standard role of stent placement in treating unresectable malignant biliary obstruction (MBO) remains unclear. The aim of this study is to compare percutaneous EB-RFA and metal stent placement (RFA-Stent) with metal stent placement alone (Stent) in treating unresectable MBO using a propensity score matching (PSM) analysis.

Methods: From June 2013 to June 2018, clinical data from 163 patients with malignant biliary obstruction who underwent percutaneous RFA-Stent or stenting alone were retrospectively analyzed using a nearest-neighbor algorithm to one-to-one PSM analysis to compare primary and secondary stent patency (PSP, SSP), overall survival (OS) and complications between the two groups.

Integration of Plasmonic Ag(I) Clusters and Fe(II) Porphyrinates into Metal-Organic Frameworks for Efficient Photocatalytic CO Reduction Coupling with Photosynthesis of Pure HO.

Efficient photocatalytic CO reduction coupled with the photosynthesis of pure HO is a challenging and significant task. Herein, using classical CO photoreduction site iron porphyrinate as the linker, Ag(I) clusters were spatially separated and evenly distributed within a new metal-organic framework (MOF), namely AgTPyP-Fe. With water as electron donors, AgTPyP-Fe exhibited remarkable performances in artificial photosynthetic overall reaction with CO yield of 36.

Highly Efficient Electrosynthesis of Urea from CO and Nitrate by a Metal-Organic Framework with Dual Active Sites.

Electrosynthesis of urea from CO and NO is a sustainable alternative to energy-intensive industrial processes. The main challenge hindering the progress of this technology lies in the development of advanced electrocatalysts that efficiently utilize abundant, low-cost CO and nitrogen sources to yield urea with both high Faradaic efficiency (FE) and current density. In this work, we designed and prepared a new two-dimensional metal-organic framework (MOF), namely PcNi-Fe-O, constructed by nickel-phthalocyanine (NiPc) ligands and square-planar FeO nodes, as the electrocatalyst for urea electrosynthesis.

Boosting the degradation of antibiotics peroxymonosulfate activation with a Cu-based metal-organic framework.

Highly efficient degradation of antibiotics is a huge challenge due to the extremely stable molecules and the potential for biological resistance. However, conventional degradation methods are limited to lower degradation rate, higher energy consumption and secondary pollution. Herein, we report a new Cu-based metal-organic framework (MOF), featuring classical planar trinuclear [Cu(µ-O)] clusters within the pores.

Rapid solar-driven atmospheric water-harvesting with MAF-4-derived nitrogen-doped nanoporous carbon.

Sorption-based atmospheric water-harvesting (AWH) could help to solve global freshwater scarcity. The search for adsorbents with high water-uptake capacity at low relative humidity, rapid adsorption-desorption kinetics and high thermal conductivity is a critical challenge in AWH. Herein, we report a MAF-4 (aka ZIF-8)-derived nanoporous carbon (NPC-800) with multiple N-doped sites, considerable micropore characteristics and inherent photothermal properties, for efficient water production in a relatively arid climate.

High-Pressure Molecular Sieving of High-Humidity CH/CH Mixture by a Hydrophobic Flexible Metal-Organic Framework.

Molecular sieving is an ideal separation mechanism, but controlling pore size, restricting framework flexibility, and avoiding strong adsorption are all very challenging. Here, we report a flexible adsorbent showing molecular sieving at ambient temperature and high pressure, even under high humidity. While typical guest-induced transformations are observed, a high transition pressure of 16.

Efficient Capture and Electroreduction of Dilute CO into Highly Pure and Concentrated Formic Acid Aqueous Solution.

High-purity CO rather than dilute CO (15 vol %, CO/N/O = 15:80:5, v/v/v) similar to the flue gas is currently used as the feedstock for the electroreduction of CO, and the liquid products are usually mixed up with the cathode electrolyte, resulting in high product separation costs. In this work, we showed that a microporous conductive Bi-based metal-organic framework (, HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) can not only efficiently capture CO from the dilute CO under high humidity but also catalyze the electroreduction of the adsorbed CO into formic acid with a high current density of 80 mA cm and a Faradaic efficiency of 90% at a very low cell voltage of 2.6 V.

Reverse Separation of Carbon Dioxide and Acetylene in Two Isostructural Copper Pyridine-Carboxylate Frameworks.

Separating acetylene from carbon dioxide is important but highly challenging due to their similar molecular shapes and physical properties. Adsorptive separation of carbon dioxide from acetylene can directly produce pure acetylene but is hardly realized because of relatively polarizable acetylene binds more strongly. Here, we reverse the CO and CH separation by adjusting the pore structures in two isoreticular ultramicroporous metal-organic frameworks (MOFs).

Construction of β-Oximino Phosphorodithioates via (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl-Promoted Difunctionalization of Alkenes with -Butyl Nitrite, PS, and Alcohols.

A (2,2,6,6-tetramethylpiperidin-1-yl)oxyl-mediated difunctionalization of alkenes with -butyl nitrite, PS, and alcohols has been developed for the synthesis of β-oximino phosphorodithioates. The reaction goes through a radical pathway with the successive installation of phosphorodithioate and an oxime group. This four-component protocol offers a practical approach to constructing a variety of β-oximino phosphorodithioates in moderate to good yields with favorable functional group tolerance.

Rapid and Visual Detection of Volatile Amines Based on Their Gas-Solid Reaction with Tetrachloro-p-Benzoquinone.

The detection of volatile amines is necessary due to the serious toxicity hazards they pose to human skin, respiratory systems, and nervous systems. However, traditional amines detection methods require bulky equipment, high costs, and complex measurements. Herein, we report a new simple, rapid, convenient, and visual method for the detection of volatile amines based on the gas-solid reactions of tetrachloro-p-benzoquinone (TCBQ) and volatile amines.

Molecular-Sieving Separation of Methanol/Benzene Azeotrope by a Flexible Metal-Organic Framework.

Separation of methanol/benzene azeotrope mixtures is very challenging not only by the conventional distillation technique but also by adsorbents. In this work, we design and synthesize a flexible Ca-based metal-organic framework MAF-58 consisting of cheap raw materials. MAF-58 shows selective methanol-induced pore-opening flexibility.

In situ electrochemical potential-induced synthesis of metal organic framework membrane on polymer support for H/CO separation.

Metal-Organic Framework (MOF) membranes act as selective layers have offered unprecedented opportunities for energy-efficient and cost-effective gas separation. Searching for the green and sustainable synthesis method of dense MOF membrane has received huge attention in both academia and industry. In this work, we demonstrate an in situ electrochemical potential-induced synthesis strategy to aqueously fabricate Metal Azolate Framework-4 (MAF-4) membranes on polypropylene (PP) support.

Utilisation of carbon dioxide and nitrate for urea electrosynthesis with a Cu-based metal-organic framework.

It is important and challenging to utilise CO and NO as a feedstock for electrosynthesis of urea. Herein, we reported a stable 2D metal-organic framework (MOF) Cu-HATNA, possessing planar CuO active sites, as an efficient electrocatalyst for coupling CO and NO into urea, achieving a high yield rate of 1.46 g h g with a current density of 44.

Metal-Organic Framework Based Sensors for Benzene Vapor.

Sensing of benzene vapor is a hot spot due to the volatile drastic carcinogen even at trace concentration. However, achieving convenient and rapid detection is still a challenge. As a sort of functional porous material, metal-organic frameworks (MOFs) have been developed as detection sensors by adsorbing benzene vapor and converting it into other signals (fluorescence intensity/wavelength, chemiresistive, weight or color, etc.

Continuously Producing Highly Concentrated and Pure Acetic Acid Aqueous Solution via Direct Electroreduction of CO.

It is crucial to achieve continuous production of highly concentrated and pure C chemicals through the electrochemical CO reduction reaction (eCORR) for artificial carbon cycling, yet it has remained unattainable until now. Despite one-pot tandem catalysis (dividing the eCORR to C into two catalytical reactions of CO to CO and CO to C) offering the potential for significantly enhancing reaction efficiency, its mechanism remains unclear and its performance is unsatisfactory. Herein, we selected different CO-to-CO catalysts and CO-to-acetate catalysts to construct several tandem catalytic systems for the eCORR to acetic acid.

Highly Efficient Electroreduction of CO to Ethanol via Asymmetric C-C Coupling by a Metal-Organic Framework with Heterodimetal Dual Sites.

The electroreduction of CO into value-added liquid fuels holds great promise for addressing global environmental and energy challenges. However, achieving highly selective yielding of multi-carbon oxygenates through the electrochemical CO reduction reaction (eCORR) is a formidable task, primarily due to the sluggish asymmetric C-C coupling reaction. In this study, a novel metal-organic framework () with unprecedented heterometallic Sn···Cu dual sites (namely, a pair of SnNO and CuN sites bridged by -N atoms) was designed to overcome this limitation.

Pore chemistry and geometry control in a metal azolate framework for one-step ethylene purification from quinary gas mixture.

In the petrochemical industry, obtaining polymer-grade ethylene from complex light-hydrocarbon mixtures by one-step separation is important and challenging. Here, we successfully prepared the Metal-Azolate Framework 7 (MAF-7) with pore chemistry and geometry control to realize the one-step separation of ethylene from cracking gas with up to quinary gas mixtures (propane/propylene/ethane/ethylene/acetylene). Based on the tailor-made pore environment, MAF-7 exhibited better selective adsorption of propane, propylene, ethane and acetylene than ethylene, and the adsorption ratios of ethane/ethylene and propylene/ethylene are as high as 1.