Publications by authors named "Xiao-Meng Qiao"
Article Synopsis
- Alcohol abuse leads to tissue and organ damage and may contribute to neuropsychiatric disorders, with DNA methylation influencing gene expression and behavior changes.
- A study with 32 male SD rats examined the effects of chronic alcohol exposure on DNA methylation in the medial prefrontal cortex (mPFC) using various tests and sequencing techniques.
- Results showed that chronic alcohol significantly increased methylation levels in the mPFC, which correlated with altered mRNA expression of several genes and elevated levels of DNA methyltransferases (DNMT3B) and MeCP2, suggesting a link between DNA methylation and alcohol abuse development.
To examine the regulatory effect of histone acetylation on memory related molecules, 34 healthy male SD rats were randomly divided into control and basolateral amygdala (BLA) intracranial positioning operation groups. In the process of conditioned place preference (CPP) training, Trichostafin A (TSA) was administrated by the route of BLA and morphine was injected into enterocoelia with dimethyl sulfoxide or saline as control. Expression levels of H3K14 acetylation and brain-derived neurotrophic factor (BDNF) in BLA were evaluated by Western blotting.
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