Publications by authors named "Xiao-Lu Ou-Yang"
Background: While there are numerous benefits to tea consumption, its long-term impact on patients with chronic kidney disease (CKD) remains unclear.
Method: Our analysis included 17,575 individuals with CKD from an initial 45,019 participants in the National Health and Nutrition Examination Survey (NHANES) (1999-2018). Individuals with extreme dietary habits, pregnancy, or non-CKD conditions were excluded.
Article Synopsis
- Heart failure (HF) is a complicated ongoing condition that involves issues with heart structure and function, with debates on how endothelial cells turn into myofibroblasts during cardiac fibrosis.
- Researchers used single-cell RNA sequencing to discover a subset of endothelial cells with a temporary fibrotic-like profile (EndoFP) following a pressure overload, which has significant implications for heart tissue remodeling.
- The study highlights that EndoFP influences cardiac dysfunction through mechanisms involving osteopontin and insulin-like growth factor-binding protein 5, suggesting potential therapeutic avenues for preventing early heart failure.
Article Synopsis
- This study analyzed NHANES data from 1999-2018, focusing on the effects of carbohydrate sources on mortality in 11,302 chronic kidney disease (CKD) patients.
- It found that CKD patients who relied more on carbohydrates from whole grains, fruits, and vegetables, while minimizing intake from fruit juice or sauces, had lower mortality rates.
- The research suggests that replacing fats with these healthier carbohydrate sources can significantly reduce all-cause mortality, possibly due to their higher fiber content.
Article Synopsis
- The study investigates the relationship between dietary total antioxidant capacity (DTAC) and mortality risk in chronic kidney disease (CKD) patients, focusing on two cohorts analyzed from the National Health and Nutrition Examination Survey.
- Results indicated that higher dietary antioxidant intake is associated with lower all-cause mortality in early-stage CKD (stages 1-2), but no such benefits were found for patients in more advanced stages (3-5).
- The findings suggest that moderate antioxidant intake may be beneficial for early-stage CKD patients, but more research is needed to determine its long-term effects on those with severe CKD.
Article Synopsis
- Muscle wasting linked to chronic kidney disease (CKD) and dialysis can lead to increased health risks, but the role of ferroptosis (a type of cell death) in this process is still being researched as a potential treatment target.
- The study involved analyzing the skeletal muscle of mice with CKD to check for signs of ferroptosis and to screen traditional Chinese herbs for their ability to prevent muscle wasting and ferroptosis.
- Results showed that a compound called Lobetyolin (LBT) significantly reduced muscle injury by inhibiting ferroptosis in both mice and lab cells, suggesting its potential as a therapeutic agent against muscle wasting related to CKD.
Article Synopsis
- Acacetin, a compound found in traditional Chinese medicine, shows significant biological activity, but its potential effects are not fully explored due to limitations in conventional drug discovery methods, which focus primarily on chemical structure.
- This study aims to develop a more suitable prediction method for traditional medicine using graph representation learning and transcriptome data, specifically to predict the properties of acacetin.
- The results show that the predictions align well with existing research, and experimental verification confirmed acacetin's effectiveness in improving insulin resistance, indicating the predictive method's reliability.
Article Synopsis
- Cardiovascular diseases are highly prevalent in advanced chronic kidney disease patients, often leading to cardiac dysfunction due to issues like hypertrophy and fibrosis, highlighting the need for new therapies aimed at preserving heart function.
- The study aimed to identify potential treatments for cardiorenal syndrome type 4 (CRS) through a combination of molecular phenotyping and various experimentation methods, including gene expression analysis and different staining techniques.
- The findings revealed that Lobetyolin (LBT) improved cardiac dysfunction in animal models and that its mechanism involves the suppression of Osteopontin (OPN) through JNK signaling, indicating a potential therapeutic pathway for CRS.
Article Synopsis
- Cardiorenal syndrome type 4 (CRS type 4) poses significant health risks globally, and Zhen-Wu decoction has been traditionally used in East Asia for treating related cardiovascular and kidney diseases, though its mechanisms are not well-studied.
- This study aimed to explore how Zhen-Wu decoction can affect uremic cardiomyopathy, providing insights for potential clinical treatments for CRS type 4.
- Results showed that Zhen-Wu decoction improved heart function in mice and suggested that the Nrf2 signaling pathway is crucial for its protective effects against oxidative stress and inflammation in kidney-related conditions.