Publications by authors named "Xiao-Long Liu"

This research aimed to systematically uncover the metastatic characteristics and survival rates of lung cancer subtypes and to evaluate the impact of surgery at the primary tumor site on cancer-specific survival in DM lung cancer. We used the Surveillance, Epidemiology, and End Results (SEER) database (2010-2019) to identify primary lung cancers with DM at presentation (M1). Kaplan-Meier (KM) survival curves were generated and compared utilizing log-rank tests.

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The Homeotic complex (Hox) genes play a crucial role in determining segment identity and appendage morphology in bilaterian animals along the antero-posterior axis. Recent studies have expanded to agricultural pests such as fall armyworm (FAW), scientifically known as Spodoptera frugiperda J. E.

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Since 2019, the novel coronavirus (SARS-CoV-2) has caused significant morbidity and millions of deaths worldwide. The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 and its variants, has further highlighted the urgent need for the development of effective therapeutic agents. Currently, the highly conserved and broad-spectrum nature of main proteases (M) renders them of great importance in the field of inhibitor study.

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The main protease (M) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) represents a promising target for antiviral drugs aimed at combating COVID-19. Consequently, the development of M inhibitor is an ideal strategy for combating the virus. In this study, we identified twenty-two dithiocarbamates (1 a-h), dithiocarbamate-Cu(II) complexes (2 a-hCu) and disulfide derivatives (2 a-e, 2 i) as potent inhibitors of M, with IC value range of 0.

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Article Synopsis
  • The study presents a new dye called PQMO-PXZ that combines thermally activated delayed fluorescence (TADF) and aggregation-induced emission (AIE) for use in organic light-emitting diodes (OLEDs).
  • PQMO-PXZ has been carefully designed and characterized, showing advantages over traditional emitters, including better luminescence efficiency and a red-shifted emission due to its strong intramolecular charge transfer properties.
  • OLED devices using PQMO-PXZ as the emissive core show impressive performance with an external quantum efficiency of 11.8%, highlighting its potential as an efficient material for OLED technology.
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A novel thermally activated delayed fluorescence (TADF) emitter, DCNP-SCF, is developed based on a dicyanophenanthrene acceptor. DCNP-SCF is prepared by a simple C-N coupling reaction. Its thermal, theoretical, photophysical, and electroluminescent properties are investigated, emphasizing its potential in organic electroluminescence devices.

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Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes with high morbidity and mortality. Ferroptosis is a form of programmed cell death (PCD), is characterized by iron overload, reactive oxygen species accumulation, and lipid peroxidation. As ferroptosis has been increasingly studied in recent years, it is closely associated with the pathophysiological process of AKI and provides a target for the treatment of AKI.

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Ferroptosis, a unique form of programmed cell death, is initiated by an excess of iron accumulation and lipid peroxidation-induced damage. There is a growing body of evidence indicating that ferroptosis plays a critical role in the advancement of tumors. The increased metabolic activity and higher iron levels in tumor cells make them particularly vulnerable to ferroptosis.

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We introduce a unique dual-function detector with an asymmetric light illumination based on the black silicon co-hyperdoped with sulfur and nitrogen for light and gas detection, and the properties in NO gas sensing and photoelectric detection are studied under various light and gas environments, respectively. Enhanced performance of the device under certain light and gas conditions is observed. When illuminated at the optimal wavelength, the gas sensors' responsivity to NO can be enhanced by approximately 5 to 200 times over 730 nm illumination, respectively.

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Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of ferroptosis in disease. Recent studies have shown a correlation between ferroptosis and the pathological mechanisms of neurodegenerative diseases, as well as diseases involving tissue or organ damage.

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Carbon dioxide (CO) production and emissions from inland waters play considerable roles in global atmospheric CO sources, while there are still uncertainties regarding notable nutrient inputs and anthropogenic activities. Urban inland waters, with frequently anthropogenic modifications and severely nitrogen loadings, were hotspots for CO emissions. Here, we investigated the spatiotemporal patterns of partial pressure of CO (pCO) and CO fluxes (FCO) in typical urban inland waters in Tianjin, China.

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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a complex pathogenesis, which involves the formation of amyloid plaques and neurofibrillary tangles. Many recent studies have revealed a close association between ferroptosis and the pathogenesis of AD. Factors such as ferroptosis-associated iron overload, lipid peroxidation, disturbances in redox homeostasis, and accumulation of reactive oxygen species have been found to contribute to the pathological progression of AD.

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Article Synopsis
  • Scientists are working on a blood test called HepaAiQ to help find liver cancer (HCC) early, which can help patients live longer.
  • They tested this blood test on a lot of people, comparing HCC patients to healthy people and those with other liver issues.
  • The blood test showed it could correctly identify HCC cases most of the time and might help doctors predict patient outcomes after treatment.
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Chemical sensing systems are vital in the growth and development of insects. Orius sauteri (Poppius) (Hemiptera: Anthocoridae) is an important natural enemy of many pests. The molecular mechanism of odorant binding proteins (OBPs) binding with common insecticides is still unknow in O.

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Background: Insects mainly rely on innate immunity against pathogen infection. Plagiodera versicolora (Coleoptera: Chrysomelidae), is a worldwide leaf-eating forest pest in salicaceous trees. However, the mechanisms behind the immunodeficiency pathway (IMD) remain poorly understood.

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The water-level fluctuations zones (WLFZs) are crucial transitional interfaces within river-reservoir systems, serving as hotspots for NO emission. However, the comprehension of response patterns and mechanisms governing NO emission under hydrological fluctuation remains limited, especially in karstic canyon reservoirs, which introduces significant uncertainty to NO flux assessments. Soil samples were collected from the WLFZs of the Hongjiadu (HJD) Reservoir along the water flow direction from transition zone (T1 and T2) to lacustrine zone (T3, T4 and T5) at three elevations for each site.

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The chemosensory system plays an important role in the host plants location. (Coleoptera: Chrysomelidae) is a worldwide leaf-eating forest pest that feeds exclusively on salicaceous trees. There is no function study of odorant binding proteins (OBPs) in .

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In yeasts, ferric reductase catalyzes reduction of ferric ion to ferrous form, which is essential for the reductive iron assimilation system. However, the physiological roles of ferric reductases remain largely unknown in the filamentous fungi. In this study, genome-wide annotation revealed thirteen ferric reductase-like (Fre) proteins in the filamentous insect pathogenic fungus Beauveria bassiana, and all their functions were genetically characterized.

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This study aimed to investigate the potential of autophagy-related genes (ATGs) as a prognostic signature for HCC and explore their relationships with immune cells and immune checkpoint molecules. A total of 483 samples were collected from the GEO database (n = 115) and The Cancer Genome Atlas (TCGA) database (n = 368). The GEO dataset was used as the training set, while the TCGA dataset was used for validation.

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Article Synopsis
  • Liver cirrhosis (LC) significantly increases the risk of developing hepatocellular carcinoma (HCC), yet current surveillance methods for HCC in LC patients are not very effective.
  • This study involved over 4,000 patients with liver cirrhosis and nearly 600 HCC cases across multiple hospitals in China, where researchers developed a screening model called PreCar Score based on cell-free DNA (cfDNA) features.
  • The PreCar Score showed better sensitivity in detecting early HCC compared to traditional methods, and when combined with ultrasound (US), it further improved early detection rates, making it a promising tool for regular HCC screening in high-risk patients.
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Ischemic stroke is a common neurological disease. Currently, there are no Food and Drug Administration-approved drugs that can maximize the improvement in ischemic stroke-induced nerve damage. Hence, treating ischemic stroke remains a clinical challenge.

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Unlabelled: As the main organic acid in fruits, malate is produced in the cytoplasm and is then transported into the vacuole. It accumulates by vacuolar proton pumps, transporters, and channels, affecting the taste and flavor of fruits. Among the three types of proton pumps (V-ATPases, V-PPases, and P-ATPases), the P-ATPases play an important role in the transport of malate into vacuoles.

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The chemosensory system is crucial during the growth and development of the moths. (Lepidoptera: Noctuidae) is one of the most destructive insect pests. However, there is little functional research on odorant-binding proteins (OBPs) in the larval stage of .

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Ionotropic receptors (IRs) play an important role in olfaction, but little is known in nondrosophila insects. Here, we report and functional characterization of IR75q.2 in the invasive moth pest .

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