Publications by authors named "Xiao-Ling Long"
Self-management is important for patients suffering from cerebrovascular events after neurosurgical procedures. An increasing number of artificial intelligence (AI)-assisted tools have been used in postoperative health management. ChatGPT is a new trend dialog-based chatbot that could be used as a supplemental tool for seeking health information.
View Article and Find Full Text PDFArticle Synopsis
- Research on spinal cord stimulation (SCS) and deep brain stimulation (DBS) for disorders of consciousness (DoC) is growing, but evidence on their effectiveness and safety is still limited due to various study flaws.
- A systematic review analyzed 20 studies involving a total of 608 patients, revealing that SCS has an overall effectiveness rate of 37% for DoC, while DBS has a higher rate of 40%.
- Adverse event rates were found to be 8.1% for SCS and 18.2% for DBS, indicating that while both treatments show potential benefits, safety concerns exist.
Deep brain stimulation (DBS) is a reversible treatment for chorea-acanthocytosis (ChAc). Its safety and efficacy remain elusive due to the low prevalence of ChAc. We aimed to investigate the safety and efficacy of DBS for ChAc by systematically reviewing literature through PubMed and EMBASE.
View Article and Find Full Text PDFArticle Synopsis
- NTCPD is a new disorder linked to mutations in the SLC10A1 gene, but more studies are needed to fully understand its impacts.
- The study examined 113 pediatric patients with NTCPD, identifying two new mutations and noting that most patients had elevated bile salts and bilirubin levels.
- Despite the challenges associated with NTCPD, patients generally had good outcomes with supportive care; doctors should consider testing for this condition in cases with specific symptoms.
Sodium taurocholate cotransporting polypeptide (NTCP), a carrier protein encoded by solute carrier family 10 member 1 (SLC10A1), is expressed in the basolateral membrane of hepatocytes, where it is responsible for the uptake of bile acids from plasma into hepatocytes. The first patient with NTCP deficiency was described in 2015. A limited number of such patients have been reported in the literature and their genotypic and phenotypic features require further investigation.
View Article and Find Full Text PDFObjective: To study the influence of cow's milk protein allergy (CMPA) on the diagnosis of functional gastrointestinal diseases (FGID) based on the Rome IV standard in infants and young children.
Methods: A total of 84 children aged 1 month to 3 years who were diagnosed with CMPA were enrolled as the case group, and 84 infants and young children who underwent physical examination and had no CMPA were enrolled as the control group. The pediatricians specializing in gastroenterology asked parents using a questionnaire for the diagnosis of FGID based on the Rome IV standard to assess clinical symptoms and to diagnose FGID.
Background: The human SLC25A13 gene encodes citrin, the liver-type mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), and SLC25A13 mutations cause citrin deficiency (CD), a disease entity that encompasses different age-dependant clinical phenotypes such as Adult-onset Citrullinemia Type II (CTLN2) and Neonatal Intrahepatic Cholestasis caused by Citrin Deficiency (NICCD). The analyses of SLC25A13 gene and its protein/mRNA products remain reliable tools for the definitive diagnoses of CD patients, and so far, the SLC25A13 mutation spectrum in Chinese CD patients has not been well-characterized yet.
Methods And Results: By means of direct DNA sequencing, cDNA cloning and SNP analyses, 16 novel pathogenic mutations, including 9 missense, 4 nonsense, 1 splice-site, 1 deletion and 1 large transposal insertion IVS4ins6kb (GenBank accession number KF425758), were identified in CTLN2 or NICCD patients from China, Japan and Malaysia, respectively, making the SLC25A13 variations worldwide reach the total number of 81.