Publications by authors named "Xiao-Liang Yan"
Article Synopsis
- - Oxabornyl polyenes are a special type of polyketide found in fungi, featuring a distinct polyene core and diverse oxygen-containing rings, with known biological activities but complex configurations.
- - The study isolated three specific oxabornyl polyenes (prugosenes A1-A3) from a fungal strain and used ozonolysis and ECD calculations to determine their absolute configurations, which were previously unassigned.
- - The prugosenes showed strong antiviral effects against the respiratory syncytial virus, with a notable effectiveness of 6.3 μM for one of the compounds, contributing to a better understanding of these compounds and their potential uses.
Chlamydia psittaci is a zoonotic pathogen found in birds and humans. Macrophages, major components of the innate immune system, can resist chlamydial infections and trigger adaptive immune responses. However, the molecular mechanisms underlying the action of macrophages against C.
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- Researchers discovered five new compounds from a rare group of natural products found in fungi, specifically analogues named simpliketals A-D and simplilactones A and B, along with five known compounds.
- They used advanced methods like NMR spectroscopy and X-ray diffraction to define the structures of these compounds and proposed a new biosynthetic pathway for their formation, differing from previously assumed methods.
- Cytotoxicity tests revealed that the newly discovered compounds exhibited varying degrees of inhibitory activity against specific cancer cell lines, with simpliketals showing weak to moderate effects.
Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme.
Beilstein J Org Chem
October 2022
Article Synopsis
- Fusicoccane-type terpenoids are a specialized group of diterpenoids known for their unique 5-8-5 ring structure and various biological activities, but only five synthesizing enzymes are currently identified.
- A new biosynthetic gene cluster from the strain ATCC 26942 has been discovered, which includes a novel fusicoccane-type diterpene synthase gene, naming it TadA.
- Experiments show that TadA creates a new compound, talaro-7,13-diene, using a different cyclization process, while another enzyme, TadB, oxidizes this compound into talaro-6,13-dien-5,8-dione.
Background: spontaneous esophageal rupture (Boerhaave's syndrome) is a rare and challenging clinical condition.
Objective: to evaluate the outcome of different surgical treatments for patients with Boerhaave's syndrome with an early diagnosis (< 24 h) and delayed diagnosis (> 24 h), using a retrospective cohort study in a tertiary referral center.
Patients And Methods: eighty-eight patients with Boerhaave's syndrome who underwent surgical treatment were identified from March 1994 to March 2019 in the First Hospital of Shanxi Medical University.