Publications by authors named "Xiao-Lei Tian"

Article Synopsis
  • Cervical cancer is the fourth most common cancer in women, and this study investigates the protein FNDC5's role in slowing down its growth.
  • Analysis revealed that higher levels of FNDC5 in patients are linked to longer survival rates, and experiments in cell lines and mouse models showed that FNDC5 can inhibit cancer cell proliferation, invasion, and migration.
  • The study found that FNDC5 works by blocking the PI3K/Akt signaling pathway, suggesting that boosting FNDC5 levels could potentially help slow down cervical cancer development.
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Enhanced proliferation and migration of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling in hypertension. Adventitial fibroblasts (AFs)-derived extracellular vesicles (EVs) modulate vascular remodeling in spontaneously hypertensive rat (SHR). This study shows the important roles of EVs-mediated miR-21-3p transfer in VSMC proliferation and migration and underlying mechanisms in SHR.

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Salt stress induced Gamma-aminobutyric acid (GABA) accumulation in maize plants. The germination of maize seeds was inhibited seriously by NaCl treatment, while exogenous GABA reduced the inhibition of NaCl on the seeds germination. Effects on SOD, POD and CAT activity of GABA were detected.

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Synopsis of recent research by authors named "Xiao-Lei Tian"

  • - Xiao-Lei Tian's recent research reveals a critical role of FNDC5 in inhibiting the growth of cervical cancer cells through the PI3K/AKT signaling pathway, highlighting potential therapeutic targets for cervical cancer treatment.
  • - Another study investigates the mechanisms by which extracellular vesicles carrying miR-21-3p from vascular fibroblasts promote the proliferation and migration of vascular smooth muscle cells in spontaneously hypertensive rats, indicating a significant interplay in vascular remodeling associated with hypertension.
  • - Tian's earlier research on the impact of gamma-aminobutyric acid (GABA) on enzyme activity in maize seedlings under salt stress demonstrates its potential to mitigate the negative effects of salinity, providing insights into stress response mechanisms in plants.