This study explores the expression and clinical importance of four proteins (HGFA, Matriptase, HAI-1, and HAI-2) in patients with acute myeloid leukemia (AML).
Bone marrow samples from 91 AML patients, including those in complete remission and healthy controls, were analyzed using qRT-PCR to measure the mRNA levels of these proteins.
Findings showed that HGFA levels were significantly higher and HAI-2 levels significantly lower in untreated AML patients compared to healthy controls, suggesting a potential disturbance in regulatory mechanisms affecting leukemia progression.