Publications by authors named "Xiao-Lan Chang"

Background: Myofascial pain syndrome (MPS) is a common disease with easy persistence and recurrence. In clinical practice, although many methods have been adopted to prevent and treat MPS, the control of MPS is still not satisfactory.

Objective: To compare the safety and effectiveness of buccal acupuncture, inactivation of trigger points (MTrPs), and their combination in the treatment of MPS.

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Objective: To evaluate ultrasound-guided inactivation of myofascial trigger points (MTrPs) combined with abdominal muscle fascia stripping by liquid knife in the treatment of postherpetic neuralgia (PHN) complicated with abdominal myofascial pain syndrome (AMPS).

Methods: From January 2015 to July 2018, non-head-and-neck PHN patients in the Pain Department, The First Affiliated Hospital of Soochow University, were treated with routine oral drugs and weekly paraspinal nerve block for two weeks. Patients with 2 < VAS (visual analogue scale) score < 6 were subjects of the study.

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HMGB3 belongs to the high-mobility group box subfamily and has been found to be overexpressed in gastric cancer. However, the expression and the role of HMGB3 in human hepatocellular carcinoma remain unknown. Here, we report that HMGB3, which is suppressed by miR-200b, contributes to cell proliferation and migration in human hepatocellular carcinoma.

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While adeno-associated virus (AAV) is widely accepted as an attractive vector for gene therapy, it also serves as a model virus for understanding virus biology. In the latter respect, the recent discovery of a non-structural AAV protein, termed assembly-activating protein (AAP), has shed new light on the processes involved in assembly of the viral capsid VP proteins into a capsid. Although many AAV serotypes require AAP for assembly, we have recently reported that AAV4, 5, and 11 are exceptions to this rule.

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Article Synopsis
  • Platelet indices, such as mean platelet volume (MPV) and plateletcrit (PCT), may indicate megakaryopoietic activity in patients with immune thrombocytopenic purpura (ITP), but their diagnostic accuracy still needs further research.
  • In comparison with myelodysplasia and control groups, patients with ITP showed higher MPV, lower PCT, and a unique platelet distribution width pattern, along with increased megakaryocytes.
  • Sensitivity and specificity tests revealed that MPV and PCT can be effective markers for diagnosing ITP, especially when combined in parallel or series tests, suggesting their potential utility in clinical settings.
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  • Metastasis to the central nervous system (CNS) is a major challenge in leukemia treatment, with key proteins like MMP-9, CCL2, and sVCAM-1 involved in tumor cell behavior, but their specific roles in this context are not fully understood.
  • A study measuring these proteins in both serum and cerebrospinal fluid (CSF) of 33 leukemia patients found that levels of sVCAM-1 and CCL2 were significantly elevated in those with CNS metastasis compared to those without and healthy controls, while MMP-9 levels showed different trends.
  • The analysis indicated potential for MMP-9, CCL2, and sVCAM-1 in CSF to serve
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Burkitt's lymphoma (BL) is a malignancy of B lymphocytes. The rapid growth rate and frequent systemic spread result in most patients presenting with advanced disease at diagnosis. Cerebrospinal fluid cytology is the gold standard (with very high accuracy) for diagnosing BL central nervous system (CNS) metastasis; however, the low sensitivity of this method limits its clinical applications.

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The aim of this study was to investigate the distribution of Enterovirus 71 (EV71) receptors SCARB2 and PSGL-1 in human tissues. The samples were chosen from archived specimens, and the profiles of two receptors were detected in the gastrointestinal tract, lung, and brain in situ by immunohistochemistry. SCARB2 was detected in all the tissues studied, and strong staining was observed in the gastric fundus gland, mucosal and glandular epithelia of the intestine.

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Aim: To compare the effects of primary culture Schwann cells and cryopreserved Schwann cells on the injured peripheral nerve regeneration.

Methods: The primary culture Schwann cells and cryopreserved Schwann cells were transplanted into the silicone tubes that bridged the resected sciatic nerves. At different time after transplantation, HRP was injected into the sciatic nerve trunks at the distal end of the silicone tubes, and then the HRP labeled neurons in dorsal root ganglions and anterior horns of spinal cord were counted.

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