Publications by authors named "Xiao-Lai Ma"
Curr Issues Mol Biol
September 2024
Article Synopsis
- - Dermatan sulfate and chondroitin sulfate are dietary supplements that can help prevent blood clots, with low-molecular-weight dermatan sulfate (LMWDS) being especially effective due to its high absorption rate.
- - The study explored improving the efficiency of chondroitin B lyases, which are enzymes used to create LMWDS, by engineering their substrate-binding domain through a design strategy that involved modifying specific amino acids.
- - Four mutations showed significant increases in enzyme activity, and the combination of two mutations (H134Y/R159K) resulted in a dramatic 3.21-fold enhancement, potentially making these enzymes more useful in pharmaceuticals and food products.
