Publications by authors named "Xiao-Juan Xin"
Background: Fever of unknown origin (FUO) has always been a challenging problem for physicians since it was first reported half a century ago. This study aimed to investigate the clinical features of FUO and to compare the clinical significance of the classical diagnostic criteria and the Chinese revised diagnostic criteria of FUO.
Methods: We retrospectively collected a series of 140 patients admitted to our hospital between September 2011 and June 2013 because of prolonged febrile illnesses (lasting at least 2 weeks, temperature ≥38.
Background: The regenerating gene (Reg), encoding lectin-related protein, was originally isolated from a rat regenerating pancreatic islets. Interleukin-22 (IL-22), a recently identified cytokine, is produced by Th 17 cells and natural killer cells. Both of them have been shown to play an important role in controlling tissue repair.
View Article and Find Full Text PDFPrevious studies indicated that the human X-ray repair complementing group 3 gene (XRCC3) plays an important role in hepatocellular carcinoma (HCC) susceptibility. We aimed to investigate the association of XRCC3 genetic polymorphism with HCC risk. This study was conducted in a Chinese Han population consisting of 300 HCC cases and 300 sex- and age-matched cancer-free controls.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the protective effects of Astragalus polysaccharides (APS) on mitochondria and its potential anti-aging activities, particularly how it counters lipid peroxidation in liver and brain mitochondria caused by Fe(2+)-Vit C.
- - Methods like TBA colorimetry and spectrophotometry were used to measure oxidative damage and mitochondrial permeability, while APS demonstrated significant scavenging of harmful free radicals such as superoxide anion and hydroxyl radicals in a concentration-dependent manner.
- - In vivo experiments using mice showed that APS could enhance the activity of key antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and inhibit damaging processes, indicating its potential
[Dissection of mechanism for the adefovir dipivoxil resistance in chronic hepatitis B patients].
Zhonghua Gan Zang Bing Za Zhi
October 2009
Objective: To explore the mechanism for adefovir dipivoxil (ADV) resistance occurred in chronic hepatitis B patients of a series of phase III clinical trails.
Methods: 30 resistant HBV strains were selected out from 177 cases of ADV treated chronic hepatitis B patients. HBV polymerase RT region were amplified by nested PCR and analyzed with the standard nucleotide sequence of HBV strains deposited in GeneBank.
It is well known that different genotypes of hepatitis B virus (HBV) have a different sensitivity to interferon-alpha or lamivudine (nucleoside analogue) antiviral therapy. However, for adefovir dipivoxil (ADV, a nucleotide analogue), the antiviral response of the different genotypes remains to be clarified. In order to evaluate the response of HBV genotypes to ADV therapy and to identify factors that might affect initial virological response, we performed a retrospective analysis on patients with chronic hepatitis B (CHB) in Chinese Han population.
View Article and Find Full Text PDF[Comparison of antiviral responses to adefovir dipivoxil therapy of genotype B and genotype C HBV infected patients].
Zhonghua Gan Zang Bing Za Zhi
June 2008
Objective: To investigate the role of HBV genotypes on their response to adefovir dipivoxil (ADV) antiviral therapy.
Methods: HBV genotypes from 177 HBeAg-positive chronic hepatitis B (CHB) patients were identified and the patients were treated with ADV 10 mg per day for 48 weeks. The clinical data in terms of serum HBV DNA seroclearance, mean HBV DNA reduction (log value), HBeAg loss, anti-HBe seroconversion and serum ALT of those patients were analyzed against their HBV genotypes.