Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy.

Autophagy is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We aimed to investigate whether the p62-Keap1-Nrf2 pathway affects the development of PAH by mediating autophagy. A PAH rat model was established using monocrotaline (MCT).

[Correlation analysis between HPLC fingerprint of astragali radix extracts and antifatigue effect].

Objective: To study the correlation analysis between the HPLC fingerprints of Astragali Radix extracts and the antifatigue effects.

Methods: Three types of extracts of Astragali Radix were obtained and arranged by uniform design for HPLC fingerprint analysis and the antifatigue effect experiment. The correlation analysis between the HPLC fingerprints of Astragali Radix extracts and the antifatigue effects were carried out with orthogonal signal correction-partial least squares (OSC- PLS) method.