Publications by authors named "Xiao-Jing Wen"

Background: The current method for liver graft implantation during the anhepatic phase is complex. Therefore, this study aimed to introduce a modified orthotopic liver transplantation (OLT) technique with major vascular reconstruction using cuff technique to simplify the process of liver graft implantation during the anhepatic phase.

Methods: Twenty-four canines were randomly assigned to two groups: the modified orthotopic liver transplantation group (M-OLT,  = 12) and the control group (n = 12).

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Article Synopsis
  • Enterovirus A71 (EV-A71) causes hand foot and mouth disease (HFMD), leading to significant global outbreaks, though its infection mechanisms remain unclear.
  • Previous research highlighted notable differences between a mild and a severe strain of EV-A71, particularly in specific nucleotide sequences in the UTRs, suggesting potential links to varying disease severity.
  • This study utilized reverse genetics to create chimeric viruses and demonstrated that modifications in UTRs altered virulence and reduced tissue damage in infected mice, indicating certain nucleotide sites play a role in EV-A71's pathogenicity.
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