Publications by authors named "Xiao-Jing Hong"
Parkinson's disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from the spice turmeric, shows promise. However, its application in PD is limited by a lack of understanding of its anti-amyloidogenic mechanisms.
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- Stabilization of G-quadruplexes (G4s) in proto-oncogene promoters can inhibit gene expression and is a potential cancer treatment strategy, but existing G4 stabilizers lack selectivity.
- A unique crescent-shaped thiazole peptide shows a preference for stabilizing a specific G4, prompting investigation into its selective binding mechanisms through simulations and molecular docking.
- The study found that the thiazole peptide and its analogue create a favorable "sandwich-like" interaction with the G4 structure, leading to increased binding affinity, primarily due to van der Waals interactions, and these insights can aid in developing new selective G4 stabilizers.
Esophageal squamous cell carcinoma (ESCC), one of the most lethal cancers, has become a global health issue. Stearoyl-coA desaturase 1 (SCD1) has been demonstrated to play a crucial role in human cancers. However, pan-cancer analysis has revealed little evidence to date.
View Article and Find Full Text PDFThe alternations in the hypoxic and immune microenvironment are closely related to the therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO@Ru@siRNA is constructed from a ruthenium-based photosensitizer (Ru) modified-TiO nanoparticles (NPs) loaded with siRNA of hypoxia-inducible factor-1α (HIF-1α). Under visible light irradiation, TiO@Ru@siRNA can elicit both Type I and Type II photodynamic effects, which causes lysosomal damage, HIF-1α gene silencing, and OSCC cell elimination efficiently.
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