Candidatus Rickettsia xinyangensis as Cause of Spotted Fever Group Rickettsiosis, Xinyang, China, 2015.

In 2015, we evaluated 221 patients with undifferentiated fever and tick bite or animal exposure in Xinyang, China, for Rickettsia infection. Three with mild disease were infected with Candidatus R. xinyangensis, which clustered with R.

Cochliomycin G, a 14-membered resorcylic acid lactone from a marine-derived fungus .

Cochliomycin G (), a new 14-membered resorcylic acid lactone, together with six known analogues (-), was isolated from the culture broth of a marine-derived fungus . The planar structure of was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the combination of empirical rules, CD data, and C chemical shift calculations. Compound exhibited potent antifouling activity against , , and , with EC values of 1.

Structures and Absolute Configurations of Diketopiperazine Alkaloids Chrysopiperazines A⁻C from the Gorgonian-Derived Fungus.

Three new diketopiperazine alkaloids, including two oxepine-containing diketopiperazines, chrysopiperazines A and B ( and ), and one quinazoline-containing diketopiperazine, chrysopiperazine C (), together with three known analogues (, , and ), were isolated from the gorgonian-derived fungus. The relative and absolute configurations of C-3 and C-15 in and , C-3 and C-14 in were established by NOE modified Marfey's analysis and electronic circular dichroism (ECD) calculations. Particularly, the absolute configurations of C-19 in and , which was very challenging to be identified due to the flexible conformation in a short aliphatic chain, were successfully determined by the vibrational circular dichroism (VCD) method, supplying with a reliable and optional method to define the absolute configurations.