Publications by authors named "Xiao-Hui Lou"
Objective: Hypoxia-inducible factor 1alpha (HIF-1α) functions as a crucial transcriptional mediator in hypoxic and ischemic brain response. We endeavored to assess the prognostic significance of serum HIF-1α in human aneurysmal subarachnoid hemorrhage (aSAH).
Methods: In this prospective, longitudinal, multicenter, and observational study of 257 patients with aSAH and 100 healthy controls, serum HIF-1α levels were quantified.
Background: Netrin-1 is an axon guidance protein, which can inhibit inflammatory reaction and stabilize the blood-brain barrier to protect against experimental brain injury. We evaluated the concentration of netrin-1 in acute intracerebral hemorrhage (ICH) patients and explored whether netrin-1 is a potential prognostic biomarker for ICH.
Methods: This study recruited a total of 126 ICH patients and 126 healthy controls.
Article Synopsis
- Neutrophil gelatinase-associated lipocalin (NGAL) levels were evaluated in patients with acute spontaneous intracerebral hemorrhage (ICH) to determine their connection to neurological outcomes.
- A study involving 106 patients and 106 controls showed that patients had significantly higher NGAL levels compared to controls, and these levels correlated with various clinical measures such as blood glucose and stroke severity.
- Increased NGAL levels were identified as a predictor of unfavorable outcomes at 90 days, indicating its potential as a prognostic marker in acute brain injuries like ICH.
Purpose: Dopamine agonists (DAs) are recommended as first-line treatment for patients with hyperprolactinemia. Generally, it is accepted that patients with hyperprolactinemia do not need lifelong medication, but the optimal timing for DA withdrawal has not been determined. The aim of this systematic review and meta-analysis is to assess the impact of DA withdrawal on the clinical outcomes of patients with hyperprolactinemia, and to explore possible factors affecting successful DA withdrawal.
View Article and Find Full Text PDFThis study was designed to investigate whether the Notch pathway is involved in the development of diffuse spinal cord astrocytomas. BALB/c nude mice received injections of CD133(+) and CD133(-) cell suspensions prepared using human recurrent diffuse spinal cord astrocytoma tissue through administration into the right parietal lobe. After 7-11 weeks, magnetic resonance imaging was performed weekly.
View Article and Find Full Text PDFObjective: Apnea is not a common preoperative manifestation of medulla cavernous malformations (CMs). The role of surgical resection in patients suffering from apnea secondary to hemorrhage from medulla CMs requires further definition.
Methods: Medical records and radiographs were reviewed retrospectively for four patients treated surgically for medulla CMs in our institution between 2008 and 2011.