Publications by authors named "Xiao-Hua Gao"
Article Synopsis
- This study investigates the impact of dexmedetomidine (DEX) as a local anesthetic adjuvant on postoperative delirium (POD) in elderly patients after elective hip surgery.
- A total of 120 patients were divided into two groups: one receiving DEX with ropivacaine (Y group) and the other receiving only ropivacaine (R group).
- Results showed that the Y group had lower rates of POD, required less remedial analgesia, and experienced better postoperative inflammatory markers, although they had a higher incidence of bradycardia compared to the R group.
Article Synopsis
- - The study focused on the frequency and risk factors of postoperative delirium in elderly patients after hip surgery, aiming to identify ways to prevent this condition.
- - Out of 97 patients analyzed, 32 (32.9%) experienced delirium post-surgery, with contributing factors including age, height, gender, and preoperative health indicators.
- - A significant finding was that the risk of delirium increased by 12% for every additional 10 years in patient age, and a history of delirium in the recovery unit was a strong predictor of developing postoperative delirium.
Objective: To evaluate the effect of the individualized positive end-expiratory pressure (PEEP) lung protection ventilation strategy by combining driving pressure (ΔP) and pulmonary ultrasound (LUS)-based titration on lung function and postoperative cognitive function in patients with chronic obstructive pulmonary disease (COPD) during laparoscopic surgery.
Methods: A total of 108 patients with COPD undergoing laparoscopic gastrointestinal surgery under general anesthesia were included in this study. They were randomly divided into three groups (n = 36): traditional volume ventilation group (Group C), fixed PEEP 5 cmHO group (Group P), and ΔP combined with LUS-based PEEP titration in the resuscitation room group (Group T).
SHR0302, as a novel Janus kinase (JAK) inhibitor 1, is used for treatment of rheumatoid arthritis (RA) in humans. A novel and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for determining the concentration of SHR0302 in human plasma. A precipitation deproteinization method was used for plasma pretreatment with methanol.
View Article and Find Full Text PDFEffect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease.
Int J Chron Obstruct Pulmon Dis
September 2021
Objective: To evaluate the effect of doxofylline on reducing the inflammatory response in mechanically ventilated rats with chronic obstructive pulmonary disease (COPD).
Methods: A total of 40 eight-week-old male Sprague Dawley rats were randomly divided into four groups of 10 rats each: a control group (group C), a model group (group M), a model + natural saline group (group N), and a doxofylline group (group D). Then mechanical ventilation, drug intervention, and the extraction of the experimental material were performed in each group.
Background: Penehyclidine hydrochloride is a selective antagonist of M1 and M3 receptors. Clinical studies suggest that it is a potential drug for the treatment of chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of penehyclidine hydrochloride on the inflammatory response of lung tissue during mechanical ventilation in rats with COPD and explore the role of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway.
View Article and Find Full Text PDFMaternal periconceptional folate status and infant atopic dermatitis: A prospective cohort study.
Pediatr Allergy Immunol
January 2021
Article Synopsis
- Maternal folate status in early pregnancy is linked to the risk of allergic disorders like atopic dermatitis (AD) in infants, but existing research is unclear.
- A study involving 458 mothers found that higher levels of red blood cell (RBC) folate increased the risk of early-onset AD in infants, with a significant association for RBC folate levels above 620 ng/mL.
- This research emphasizes the potential importance of managing folate levels during early pregnancy to potentially decrease the risk of AD in babies.
A novel and selective liquid chromatographic-mass spectrometric method (LC-MS/MS) has been established and validated for simultaneous determination of subutinib and active metabolite in human urine. Urine samples were extracted by liquid-liquid extraction with ethyl acetate and separated on a Wondasil C18 (150 × 2.1 mm, 3.
View Article and Find Full Text PDFObjective: To investigate the effect of 17 beta-estradiol (E2) on T-type calcium currents (ICaT) in spermatogenic cells.
Methods: Ca2+ currents were obtained in acutely dissociated mouse spermatogenic cells by the whole-cell patch clamp technique and the effects of E2 on ICaT were observed.
Results: E2 at the concentrations of 1, 10 and 100 micromol/L significantly inhibited ICaT in the mouse spermatogenic cells, with the KC50 value of 8.
Objective: To investigate the effects of Flunarizine (Flu) on T-type calcium currents (ICaT) in spermatogenic cells.
Methods: Ca2+ currents were obtained in acutely dissociated mouse spermatogenic cells using whole-cell patch clamp technique and the effects of Flu on ICaT were observed.
Results: Flu of 0.