Publications by authors named "Xiao-Hu Lu"

Article Synopsis
  • The study investigates the effects of rhCHK1, a recombinant protein, on improving heart cell survival and growth after ischemia/reperfusion injury in pigs, with findings suggesting enhanced cardiac repair and function.
  • Researchers found that injecting rhCHK1 not only stimulated heart cell division and reduced inflammation within days but also improved overall heart function and minimized damage over a month post-injury.
  • The mechanism behind these effects involves CHK1 binding to and activating specific sites on the PKM2 protein, leading to changes in metabolism that support heart cell renewal and repair processes.
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Systems exhibiting parity-time () symmetry are, in general, non-Hermitian systems, in which exceptional points (EPs) emerge when the system transits from the -symmetric phase to the broken--symmetric phase. Based on the abnormal exponential amplification effect in EPs, it is often used to generate, control and transmit light in non-Hermitian systems. In this paper, we theoretically analyze the generation of the frequency components at the sum sideband by considering the nonlinear terms of the optomechanical dynamics in a double-probe-field-driven mechanical -symmetric system.

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Based on the ozone monitoring data from 2014 to 2018, we presented the variation of ozone concentration in Xi'an and revealed the effects of ozone concentration by meteorological factors based on the generalized additive model (GAM). The results showed that ① with increasing ozone concentration year by year, the assessment standard of ozone pollution was overtaken by three consecutive years since 2016. However, the rising trend was slowed down since 2017 as a result of the strengthened pollution control during summer.

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We investigate theoretically the generation and enhancement of sum sideband in a quadratically coupled optomechanical system with parametric interactions. It is shown that the generation of frequency components at the sum sideband stems from the nonlinear optomechanical interactions via two-phonon processes in the quadratically coupled optomechanical system, while an optical parametric amplifier (OPA) inside the system can considerably improve the sum sideband generation (SSG). The dependence of SSG on the system parameters, including the power of the control field, the frequency detuning of the probe fields and the nonlinear gain of OPA are analyzed in detail.

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The surgical treatment for aortic diseases remains a challenge for any cardiac surgeon. The use of sutureless ring connector in aortic anastomosis can simplify the procedure and shorten anastomosis time. Therefore, we developed a novel device for sutureless aortic anastomosis.

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Objective: To evaluate the biocompatibility of polylactic-co-glycolic acid (PLGA) for culturing bFGF gene-transfected bone marrow stromal cells (BMSCs) and assess the feasibility of this cell complex for repairing cartilage defect in rabbits using tissue engineering method.

Methods: BMSCs transfected by bFGF gene were cultured on PLGA matrix to assess the biocompatibility of PLGA. The cell complex was then implanted into the cartilage defect in rabbits, and its effect in cartilage defect repair was evaluated by histological observation and immunohistochemical staining.

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Objective: To investigate approach and possibility of transferring basic fibroblast growth factor (bFGF) gene into rabbit bone marrow stromal cells (BMSCs).

Methods: The eukaryotic expression vectors harboring bFGF cDNA were constructed and transfected into rabbit BMSCs mediated by liposome. The transcription and expression of bFGF gene in the transfected BMSCs were detected by means of morphological observation, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and RT-PCR.

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