Publications by authors named "Xiao-Hong Qiao"
Article Synopsis
- - Cyclosporine (CsA) is part of the primary treatment for acquired aplastic anemia in kids, and researchers developed a population pharmacokinetic (PK) model to personalize dosing for Chinese pediatric patients based on their unique characteristics.
- - Data from 681 CsA concentration samples and lab results from 157 patients were analyzed using a nonlinear mixed-effect model, identifying key factors like body weight and total bilirubin levels that affect CsA's behavior in the body.
- - The final PK model indicated that a typical 28 kg child has a clearance rate of 29.1 L/h and a central volume of distribution of 325 L, allowing for tailored CsA therapies while finding that factors like gender and age had
[Natural history of moderate aplastic anemia in children and effects of immunosuppressive therapy].
Zhonghua Er Ke Za Zhi
December 2008
Objective: In contrast to severe aplastic anemia (SAA), the appropriate management of patients with moderate aplastic anemia (MAA) is unclear. Recently, it was reported that when childhood MAA was treated with supportive care alone, 2/3 of patients progressed to SAA, and therefore patients with MAA should be treated with immunosuppressive (IS) therapy in time. The present study aimed to review the natural history, the rate of progression to SAA and outcome of children with MAA seen at our institution over the past 12 years and to explore the relationship between the effectiveness of IS therapy and the immune mediated pathological mechanism.
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